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Short-term toxicity to fish

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Description of key information

The NOEC ( No Observed Effect Concentration) was > 0.0824 mg/L since no mortality was observed in the present test concentration during the exposure.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.082 mg/L

Additional information

A 96 hour acute toxicity test of FP-100 with Medaka was conducted.

Ten fish we used in an exposure level of 0.0100 mg/L (nominal concentration), a vehicle and a control. The water temperature was maintained within 23 to 25°C. The test solutions were renewed every 24 hours, as the semi-static method. In preliminary tests the solubility of the test item to dilution water was not reproducible, and the concentration in disperwsed suspension containing the test item was very low and showed variation. So the test concentration was decided from the concentration which was expected to maintain the concentration in the test solution with N,N-dimethyl formamide (DMF) during exposure and be more than the solubility.

The measured concentrations of the test item in the test solution were 80.7 and 96.5% of the nominal concentration at the start of the exposure and the renewal at 72 hours, and 76.6 and 77.3% at the end of the exposure before the renewal at 24 hours. The results were estimated based on the time weighted mean of the measured concentrations, 0.0824 mg/L because the measured values of the test item concentration in the test solution were not kept within the +/- 20% of the nominal concentration.

Consequently, both of the 48 -hour and 96 -hour LC50's (Median Lethal concentration) of FP-100 were > 0.0824 mg/L

The NOEC ( No Observed Effect Concentration) was > 0.0824 mg/L since no mortality was observed in the present test concentration during the exposure.

The measured concentrations at 24 hours after preparation of the test solution were not kept within +/- 20% of the nominal concentration. However, it was considered that the concentration in the test solution was maintained higher than the solubiltiy of the test item to that of the test medium expected from the measured values at 24 hours after the preparation of the test solution. Therefore, it is concluded that the test tiem has no potential for adverse effects on the test organism near the solubiltiy of the test item to the test medium.

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