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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short summary of proprietary study available, contributing to weight of evidence.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1930

Materials and methods

Principles of method if other than guideline:
A 10% solution of 3-methoxybutan-1-ol in water was injected subcutaneously to 1 guinea pig at a single dose of 0.1 g/kg and to another guinea pig, at the same dose, on 6 consecutive days (see 7.5.4). Rats were also dosed subcutaneously with a 10% solution of 3-methoxybutan-1-ol in water at a single dose of 0.5 g/kg and 1 g/kg.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methoxybutan-1-ol
EC Number:
219-741-8
EC Name:
3-methoxybutan-1-ol
Cas Number:
2517-43-3
Molecular formula:
C5H12O2
IUPAC Name:
3-methoxybutan-1-ol
Details on test material:
Name of test material (as cited in study report): Methoxy-3-butanol-1

Test animals

Species:
other: guinea pig and rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data.

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
other: oil
Details on exposure:
A 10% solution of 3-methoxybutanol was injected subcutaneously, as a single dose, to 1 guinea pig and to rats. No further details provided.
Doses:
0.1 g/kg - guinea pig; 0.5 or 1.0 g/kg - rats
No. of animals per sex per dose:
1 (rats not specified)
Control animals:
no
Details on study design:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: No effect level (rat)
Effect level:
1 000 mg/kg bw
Remarks on result:
other: a single dose of.500 mg/kg and 1000 mg/kg did not cause any symptoms in rats
Clinical signs:
No adverse clinical signs were seen.

Applicant's summary and conclusion

Conclusions:
A single subcutaneous injection of a 10% solution of 3-methoxybutanol did not cause any adverse effects to a guinea pig (at a dose of 100 mg/kg) or to rats at a dose of 500 or 1000 mg/kg.
Executive summary:

A 10% solution of 3 -methoxybutanol in water was injected subcutaneously to a guinea pig at a dose of 100 mg/kg and to rats at a dose of 500 or 1000 mg/kg on a single occasion. There were no adverse clinical signs. 3-methoxybutan-1-ol, 10% in water, was of low toxicity by the subcutaneous route to guinea pigs at a dose level of 100 mg/kg/day and to rats at 500 or 1000 mg/kg.