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EC number: 219-741-8 | CAS number: 2517-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short summary of proprietary study available, contributing to weight of evidence.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 930
Materials and methods
- Principles of method if other than guideline:
- A 10% solution of 3-methoxybutan-1-ol in water was injected subcutaneously to 1 guinea pig at a single dose of 0.1 g/kg and to another guinea pig, at the same dose, on 6 consecutive days (see 7.5.4). Rats were also dosed subcutaneously with a 10% solution of 3-methoxybutan-1-ol in water at a single dose of 0.5 g/kg and 1 g/kg.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-methoxybutan-1-ol
- EC Number:
- 219-741-8
- EC Name:
- 3-methoxybutan-1-ol
- Cas Number:
- 2517-43-3
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 3-methoxybutan-1-ol
- Details on test material:
- Name of test material (as cited in study report): Methoxy-3-butanol-1
Constituent 1
Test animals
- Species:
- other: guinea pig and rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: oil
- Details on exposure:
- A 10% solution of 3-methoxybutanol was injected subcutaneously, as a single dose, to 1 guinea pig and to rats. No further details provided.
- Doses:
- 0.1 g/kg - guinea pig; 0.5 or 1.0 g/kg - rats
- No. of animals per sex per dose:
- 1 (rats not specified)
- Control animals:
- no
- Details on study design:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: No effect level (rat)
- Effect level:
- 1 000 mg/kg bw
- Remarks on result:
- other: a single dose of.500 mg/kg and 1000 mg/kg did not cause any symptoms in rats
- Clinical signs:
- No adverse clinical signs were seen.
Applicant's summary and conclusion
- Conclusions:
- A single subcutaneous injection of a 10% solution of 3-methoxybutanol did not cause any adverse effects to a guinea pig (at a dose of 100 mg/kg) or to rats at a dose of 500 or 1000 mg/kg.
- Executive summary:
A 10% solution of 3 -methoxybutanol in water was injected subcutaneously to a guinea pig at a dose of 100 mg/kg and to rats at a dose of 500 or 1000 mg/kg on a single occasion. There were no adverse clinical signs. 3-methoxybutan-1-ol, 10% in water, was of low toxicity by the subcutaneous route to guinea pigs at a dose level of 100 mg/kg/day and to rats at 500 or 1000 mg/kg.
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