Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-210-1 | CAS number: 16066-35-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a guideline study but with considerable documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- HF Smythe, CP Carpender, CS Weil, UC Pozzani, JA Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal 23:95-107
Materials and methods
- Principles of method if other than guideline:
- Males only; 5 animals per dose, a logarithmic series of single doses; mortality recorded through 14 days
- GLP compliance:
- no
- Test type:
- other: not reported
- Limit test:
- no
Test material
- Reference substance name:
- Benzenesulphonic acid
- EC Number:
- 202-638-7
- EC Name:
- Benzenesulphonic acid
- Cas Number:
- 98-11-3
- IUPAC Name:
- benzenesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): benzenesulfonic acid
- Substance type: organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: in house colony
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90-120 g
- Fasting period before study: not reported
- Housing: not reported
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reported
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS - not reported
IN-LIFE DATES: From: To: - not reported
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- not reported other than a logarithmic series differing by a factor of two
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: not reported - Statistics:
- method of Thompson using Tables of Weil
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1 104 mg/kg bw
- Based on:
- not specified
- Mortality:
- not reported
- Clinical signs:
- other: not reported
- Gross pathology:
- not reported
Any other information on results incl. tables
The LD50 is >0.89 (0.36 - 3.21) ml/kg bw which is equivalent to 1104 mg/kg bw (d = 1.24 g/cm3)
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test substance has a relatively low acute oral toxicity
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
