Registration Dossier
Registration Dossier
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EC number: 240-210-1 | CAS number: 16066-35-6
Endpoint summary
Administrative data
Description of key information
Corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The aromatic sulphonic acids, as represented by toluene-4-sulphonic acid (CAS No. 104-15-4) and hydroxybenzenesulphonic acid (CAS No. 1333-39-7) are corrosive to the skin and eye.
A GLP guideline skin irritation study with toluene-4-sulphonic acid conducted in 1988 indicated corrosive properties after 4 hours of exposure; and the effects were not reversible after 7 days. 3-minute exposures followed by washing with water resulted in a much less severe effect that was reversible within 72 hours. During the test on sensitisation the primary skin irritation effect of 0.01 -20% solutions of toluene-4-sulphonic acid
monohydrate in 0.9% NaCl solution was studied. The animals was exposed 24 hours to an occlusive application. An irritation effect was only found with 20%toluene-4-sulphonic acid
, but in a study by Loden et al (1985) with rabbits, without occlusion and after 4 hours, the same concentration in pure water solution caused burns
A 1962, non-guideline eye irritation study with a 65% solution hydroxybenzenesulphonic acid indicated corrosion of the eye even after 5 seconds of exposure. There was no reversibility indicated within 14 days.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on existing tests the substance is classificated as "Corrosive" following Regulation 1272/2008. Based on existing studies a tested concentration < 20% didn't caused burns or irreversible effect. Therefore a concentration limit of 20% is set, under that the substance can be classified as "Irritant"
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