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Description of key information


Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

The aromatic sulphonic acids, as represented by toluene-4-sulphonic acid (CAS No. 104-15-4) and hydroxybenzenesulphonic acid (CAS No. 1333-39-7) are corrosive to the skin and eye.

A GLP guideline skin irritation study with toluene-4-sulphonic acid conducted in 1988 indicated corrosive properties after 4 hours of exposure; and the effects were not reversible after 7 days. 3-minute exposures followed by washing with water resulted in a much less severe effect that was reversible within 72 hours. During the test on sensitisation the primary skin irritation effect of 0.01 -20% solutions of toluene-4-sulphonic acid

monohydrate in 0.9% NaCl solution was studied. The animals was exposed 24 hours to an occlusive application. An irritation effect was only found with 20%

toluene-4-sulphonic acid

, but in a study by Loden et al (1985) with rabbits, without occlusion and after 4 hours, the same concentration in pure water solution caused burns

A 1962, non-guideline eye irritation study with a 65% solution hydroxybenzenesulphonic acid indicated corrosion of the eye even after 5 seconds of exposure. There was no reversibility indicated within 14 days.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

Based on existing tests the substance is classificated as "Corrosive" following Regulation 1272/2008. Based on existing studies a tested concentration < 20% didn't caused burns or irreversible effect. Therefore a concentration limit of 20% is set, under that the substance can be classified as "Irritant"