Acetaldehyde oxime

Endpoint summary

Description of key information

Absorption of AAO following oral administration is > 97%.
Elimination was very rapid and occurred mainly via the expired air and to a lesser extent via the urine. Excretion via the faeces was minimal (1-3%). Overall, 76-88% of the radioactivity was excreted during the 96 hour period.
The highest 14C tissue concentrations were found in the liver and kidney.

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

97

Additional information

One toxicokinetic study (Unger and Salerno 1982) is available. In this study, AAO was administered orally to rats, at several dose levels ranging from 0.75 mg/kg to 750 mg/kg. Dosing solutions were prepared by diluting radiolabeled¹⁴C-AAO with unlabeled AAO.

 

Although elimination was not complete, a relatively large portion of the administered radioactivity was excreted during the 96 h period (76-88%). Some of the administered radioactivity remained in the tissues (12-24%). The major route of elimination of radioactivity was as¹⁴CO₂in the expired air, accounting for 63-68% of the radioactivity administered. Urinary excretion accounted for 11-16% of the radioactivity administered, and excretion in the feces was minimal (1-3%). Elimination of radioactivity via the expired air and the urine was essentially complete by 24 h in all but animals given the highest dose (750 mg/kg).

 

Radioactivity remaining in the liver, kidneys, testes, muscle, spleen, fat and blood was determined at the end of each experiment. The highest tissue concentrations of radioactivity were found in the liver and the kidney. The relationship between exposure level and concentration of radioactivity in all studies examined, except fat, was linear.