Registration Dossier
Registration Dossier
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EC number: 203-479-6 | CAS number: 107-29-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not GLP but performed according to a US regulation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.40
- GLP compliance:
- no
- Remarks:
- Study performed in 1975
- Limit test:
- no
Test material
- Reference substance name:
- Acetaldehyde oxime
- EC Number:
- 203-479-6
- EC Name:
- Acetaldehyde oxime
- Cas Number:
- 107-29-9
- Molecular formula:
- C2H5NO
- IUPAC Name:
- acetaldehyde oxime
- Details on test material:
- - Test material: 50% AAO
- Appearance: clear liquid
Constituent 1
Test animals
- Species:
- rabbit
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: adult
- Source: selected from healthy, acclimated animals
Administration / exposure
- Type of coverage:
- not specified
- Doses:
- 0.02, 0.2, 0.43, 0.928, 2.0 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Other examinations performed: examination of toxicological and pathological signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD0 for 50% solution of AAO in water.
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 1 000 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: LD0 for AAO (undilluted)
- Gross pathology:
- No effects
Applicant's summary and conclusion
- Conclusions:
- The acute dermal LD50 of acetaldehyde oxime is > 2.0 g/kg body weight when tested on rabbits with intact skin. It produced no gross toxicological or pathological effects.
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