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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not GLP, but performed according to a US regulation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Draize procedure as described in 16 CFR 1500.41
GLP compliance:
no
Remarks:
Study from 1974

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetaldehyde oxime
EC Number:
203-479-6
EC Name:
Acetaldehyde oxime
Cas Number:
107-29-9
Molecular formula:
C2H5NO
IUPAC Name:
acetaldehyde oxime
Details on test material:
- Test material: 50% AAO
- Appearance: water-white liquid

Test animals

Species:
rabbit
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: selected from healthy, acclimated animals
- Age at study initiation: adult

Test system

Preparation of test site:
other: shaved: left half of the shaved area intact, right half of the shaved area abraded
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied: 0.5 mL or 0.5 g
Duration of treatment / exposure:
24 h
Observation period:
72 h
Number of animals:
6
Details on study design:
TEST SITE
- Type of wrap if used: square patch of surgical gauze measuring 1 inch x 1 inch

SCORING SYSTEM: Draize procedure as described in 16CFR 1500.41

Results and discussion

In vivo

Irritant / corrosive response data:
AAO produced
- erythema in 5 animals, in 4 on the intact and the abraded area, and in 1 only on the abraded skin.
- edema in 3 animals, in 2 on the intact and the abraded area, and in 1 only on the abraded skin.
Other effects:
1 animal died.

Any other information on results incl. tables

 Findings Exposure time (h)  Exposure unit (value)                
    Rabbit 1  Rabbit 2  Rabbit 3  Rabbit 4  Rabbit 5  Rabbit 6 
Erythema and eschar formation              
intact skin  24  1  1  0  +  1  1
intact skin 72  0  0  0  +  0  0 
abraded skin  24  1  4  1  +  1  1 
abraded skin  72  2  4  0  +  0  0
Edema formation              
intact skin 24  0 0  0  +  1  1 
intact skin  72  0  0  0  +  0  0 
abraded skin  24  0  1  0  +  1  1 
abraded skin  72  0  0  0  +  0  0 

Applicant's summary and conclusion

Conclusions:
The test material, 50% AAO, is a mild irritant to intact skin.