2-(chloromethyl)-4-methylquinazoline

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2006-11-10

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

issued by 2004-12-21

Type of method:

flask method

Key result

Water solubility:

3.11 g/L

Temp.:

20 °C

pH:

>= 4.12 - <= 4.4

Remarks on result:

other: temperature was kept constant within +/-1°C

Details on results:

Preliminary test: Water solubility proved to be higher than 1 g/L, therefore the shake flask method was used.

Water solubility results at 20 +/- 1  °C:

Measured concentration after 24 hours (g/L)	pH	Measured concentration after 48 hours (g/L)	pH	Measured concentration after 72 hours (g/L)	pH	Solubility of the test item (g/L)
3.05	4.19	3.07	4.40	3.06	4.19	3.11+/- 0.085
3.10	4.14	3.12	4.38	3.18	4.16
3.06	4.12	3.15	4.35	3.17	4.28
Mean: 3.07		Mean: 3.11		Mean: 3.14

Conclusions:

The water solubility was determined to be 3.11 g/L +/- 0.085 g/L at 20 °C +/-1°C using the sheke-flash method according to OECD Test Guideline 105 (1995) and EC Method A.6 (1992);

Description of key information

Water solubility: 3.11 g/L +/- 0.085 g/L at 20 °C +/-1°C .

Method: OECD Test Guideline 105 (1995) and EC Method A.6 (1992); (by shake-flash method).

Key value for chemical safety assessment

Water solubility:

3.11 g/L

at the temperature of:

20 °C