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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

With high probability, 1-ethylpiperazine (CAS 5308-25-8) is considered to be acutely not harmful to aquatic organisms.

Additional information

Short-term toxicity to fish

With high probability, the substance is acutely not harmful to fish.

96-h LC50 = 316 mg/L (Leuciscus idus, DIN 38412, part 15, nominal, not pH-adjusted, BASF AG, 1990, rep. no.: 10F0950/885185).


Short-term toxicity to aquatic invertebrates:

With high probability the substance is acutely not harmful to aquatic invertebrates.

48-h EC50 = 199.3 mg/L (Daphnia magna, EU Method C.2, nominal, not pH-adjusted, BASF AG, 1988, 1/0002/2/88-0002/88).


Growth inhibition to aquatic algae:

With high probability acutely not harmful to algae.

The assessment is based on a read-across approach to a structurally similar substance: 1-methylpiperazine (CAS 109-01-3):

72 -h ErC50 > 352 mg/L, 72 -h ErC10 > 352 mg/L (OECD 201, nominal, analytically verified, pH-adjusted, BASF SE, 2013, rep. no.: 110907AG).


Toxicity to microorganisms:

The substance is not anticipated to inhibit the degradation activity of activated sludge when introduced in appropriately low concentrations.

1)     30 -min EC20 > 1000 mg/L. (domestic activated sludge, OECD 209, nominal, BASF AG, 1990, rep. no.: 01.0387/88)

2)     17-h EC10 = 141.4 mg/L (Pseudomonas putida, DIN 38412, part 8, nominal, BASF AG, 1988, rep. no.: 9/0843/88)

Based on the available data, 1-ethylpiperazine (CAS 5308-25-8) is considered with high probability to be acutely not harmful to aquatic organisms.