Registration Dossier

Environmental fate & pathways

Hydrolysis

Currently viewing:

Administrative data

Endpoint:
hydrolysis
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the substance is highly insoluble in water
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
See the link in the 'Cross-reference' table.
Cross-reference
Reason / purpose for cross-reference:
data waiving: supporting information
Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 April - 21 June 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to other study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
column elution method
Water solubility:
< 0.522 µg/L
Conc. based on:
other: Yttrium
Temp.:
20 °C
pH:
>= 6.9 - <= 7
Key result
Water solubility:
< 0.663 µg/L
Conc. based on:
other: Yttrium Oxide (Y2O3)
Temp.:
20 °C
pH:
>= 6.9 - <= 7
Details on results:
Turbidity of the eluates was <0.2 NTU, thus no undissolved particles were detected in the eluates.
In all samples, a small Yttrium response was detected. This response was below the lowest calibration solution.
<0.522 µg/L yttrium was analysed at 12 and 24 ml/h flow rate with a pH of 6.9 and 7.0 respectively, with 0.5 µg/L being the lowest calibration solution. This is equivalent to < 0.663 µg/L yttrium oxide concentration.
The test substance signal in the samples from the blank column was below that of the lowest calibration standard.
Conclusions:
The substance is insoluble in water. In a study according to current OECD/EC/EPA test guidelines, the water solubility was determined using the column elution method resulting in a water solubility of <0.663 µg/L, expressed as Yttrium Oxide (Y2O3).

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion