Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 271-591-2 | CAS number: 68585-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Several in vivo skin and eye irritating studies are available both with substance analogues yttrium oxide and europium oxide. None of the studies indicated skin effects and only slight eye irritation was seen, thus no further studies were performed. The results with the substance analogues are read-across to the substance.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The rationale to read across the data is attached in section 13.
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 8
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritant / corrosive response data:
- There were no signs of dermal irritation. Yttrium oxide is not considered to be a skin irritant.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a primary dermal irritation study, 6 New Zealand Albino rabbits were dermally exposed to 0.5 g of yttrium oxide (purity unknown) for 24 hours to ca. 2.5 cm² of one intact and one abraded skin site. Test sites were covered with an occlusive dressing for 24 hours. Animals were then observed for 3 days. Irritation was scored by the method of Draize. In this study, yttrium oxide is not a dermal irritant. This skin irritation study is classified as acceptable. It does satisfy the guideline requirement for a skin irritation study (16CFR 1500 -41) in the rabbit. This result is read across to yttrium oxide, europium-doped.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- The rationale to read across the data is attached in section 13.
- Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 8
- Remarks on result:
- other: scored 24 and 72 hours after initial exposure
- Irritant / corrosive response data:
- No signs of dermal irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an in vivo skin irritation study with europium oxide, the substance is considered to be not irritating to the skin. This result is read across to yttrium oxide, europium doped.
- Executive summary:
In an in vivo skin irritation study, rabbits were exposed to a single dose of 0.5 g europium oxide via occlusive application to the intact and abraded skin for 24 hours. The rabbits were observed for 72 hours and scored according to Draize. The primary dermal irritation index was 0, therefore, based on this study the substance europium oxide is considered to be not irritating to the skin. This result is read across to yttrium oxide, europium doped.
Referenceopen allclose all
The justification of this analogue approach is described in a report, see section 13 of the IUCLID and in chapter 1.4 of the CSR.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Justification for type of information:
- The rationale to read across these data is attached in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Remarks:
- of 3 rabbits (with unwashed eye)
- Time point:
- 24 h
- Score:
- 5.3
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: Scores decreased significantly from 24 to 48 and to 72 hours. At 72 hours score was only 0.7, showing reversibility.
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Remarks:
- of 3 rabbits (with washed eye)
- Time point:
- 24 h
- Score:
- 7.3
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: Scores decreased significantly from 24 to 48 and to 72 hours. At 72 hours score was only 0.7, showing reversibility.
- Irritant / corrosive response data:
- - Individual (total) scores are not available. Only the mean of the 3 rabbits: no further details are available.
- Mean scores for unwashed eyes at 24, 48 and 72 hours were 5.3, 3.3 and 0.7, respectively
- Mean scores for washed eyes at 24, 48 and 72 hours were 7.3, 2.0 and 0.7, respectively - Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an in vivo eye irritation study with europium oxide, the substance is considered to be not irritating to the eye. This result is read across to yttrium oxide, eurpium doped.
- Executive summary:
In an in vivo eye irritation study, rabbits were exposed to a single dose of 0.1 g europium oxide in the left eye. The eyes of three rabbits were washed 30 seconds post application, of three rabbits the eyes were not washed. The rabbits were observed for 72 hours and scored according to Draize (1944). Based on the results, based on the MMTS, the test substance is considered to be minimally irritating to both the unwashed and washed eye. Although there was a mean total score after 72 hours (0.7), a clear decrease from 24 to 48 hours and from 48 to 72 hours was shown. Based on this study, europium oxide is not classified according to CLP Regulation (EC) No. 1272 /2008. This result is read across to yttrium oxide, eurpium doped.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The rationale to read across the data is attached in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Remarks:
- of 3 rabbits
- Time point:
- 24 h
- Score:
- 13
- Max. score:
- 110
- Remarks on result:
- other: Unwashed
- Irritation parameter:
- other: Mean total scores (unwashed)
- Basis:
- mean
- Remarks:
- of 3 rabbits
- Time point:
- other: at 24, 48 and at 72 hours
- Score:
- >= 0.7 - <= 13
- Max. score:
- 110
- Remarks on result:
- other: Unwashed: 13 (24h); 3.7 (48h); 0.7 (72h)
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Remarks:
- of 3 rabbits
- Time point:
- 24 h
- Score:
- 9
- Max. score:
- 110
- Remarks on result:
- other: Washed
- Irritation parameter:
- other: Mean total scores (washed)
- Basis:
- mean
- Remarks:
- of 3 rabbits
- Time point:
- other: at 24, 48 and at 72 hours
- Score:
- >= 0 - <= 9
- Max. score:
- 110
- Remarks on result:
- other: Washed: 9 (24h); 2 (48h); 0 (72h)
- Irritant / corrosive response data:
- - Individual (total) scores are not available. Only the mean of the rabbits, as reported above: no further details are available.
- Yttrium oxide is considered to be mildly and minimally irritating to the unwashed and washed eye, respectively. Based on the MMTS. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a primary eye irritation study, 0.1 g of yttrium oxide (purity unknown) was instilled into the left eye of New Zealand Albino rabbits (6 animals). Three treated eyes were rinsed after 30 seconds. Animals were then observed for 3 days. Irritation was scored by the method of Draize (1944). In this study, yttrium oxide is slightly irritating to the eye, but not classified according to EU criteria. This eye irritation study is classified as acceptable. It does satisfy the guideline requirement for an eyes irritation study (OPPTS 870.2400) in the rabbit. This result is read across to yttrium oxide, europium doped.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No study with yttrium oxide, europium doped is available. However, several studies with yttrium oxide and also with europium oxide are present. The justification for this analogue approach is described in a report (see section 13 of IUCLID).
Skin irritation:
In an in vivo skin irritation study, 6 New Zealand Albino rabbits were dermally exposed to 0.5 g of yttrium oxide for 24 hours to ca. 2.5 cm² of one intact and one abraded skin site. Test sites were covered with an occlusive dressing for 24 hours. Animals were then observed for 3 days. Irritation was scored by the method of Draize. The primary dermal irritation index, the average of the scores of all animals and time points for erythema and oedema combined, was 0, therefore yttrium oxide is considered to be not skin irritating.
In another in vivo skin irritation study, rabbits were exposed to a single dose of 0.5 g europium oxide via occlusive application to the intact and abraded skin for 24 hours. The rabbits were observed for 72 hours and scored according to Draize. The primary dermal irritation index was 0, therefore europium oxide is considered to be not skin irritating.
Eye irritation:
In an in vivo eye irritation study, 0.1 g of yttrium oxide was instilled into the left eye of New Zealand Albino rabbits (6 animals). 3 treated eyes were rinsed after 30 seconds. Animals were then observed for 3 days. Irritation was scored by the method of Draize. The primary eye irritation index was 0 -13 (with a possible max of 110), therefore yttrium oxide is considered to be not eye irritating.
In another in vivo eye irritation study, rabbits were exposed to a single dose of 0.1 g europium oxide in the left eye. The eyes of three rabbits were washed 30 seconds post application, of three rabbits the eyes were not washed. The rabbits were observed for 72 hours and scored according to Draize. The mean scores from 24 to 72 hours were 3.3 and 3.1 respectively (out of a max of 110), not being fully reversible at 72 hours (0.7) but showing a clear decrease from 24 to 48 hours and from 48 to 72 hours. Therefore, the effect is considered reversible after 14 days and europium oxide is considered to be not eye irritating.
Justification for classification or non-classification
Based on the available studies yttrium oxide, europium doped does not have to be classified for skin and eye irritation according to CLP Regulation (EC) No. 1272 /2008 including its amendments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.