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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Manufacturer/producer data without proof.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2008

Materials and methods

Principles of method if other than guideline:
No data referring to the test method were reported.

GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl cyanoacetate
EC Number:
203-288-8
EC Name:
Methyl cyanoacetate
Cas Number:
105-34-0
Molecular formula:
C4H5NO2
IUPAC Name:
methyl 2-cyanoacetate
Details on test material:
no details on test material as used in the original study are available.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 062 mg/kg bw
Remarks on result:
other: no more data available

Any other information on results incl. tables

According to a MSDS by Sigma-Aldrich, the LD50 for acute oral toxicity of methyl cyanoacetate in rat is 3062 mg/kg bw.

Applicant's summary and conclusion