Sodium periodate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 April 2012 - 29 June 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

other: ‘Particle Size Distribution, Fibre Length and Diameter Distribution', June 1996 European Commission technical guidance document

GLP compliance:

yes (incl. QA statement)

Type of method:

sieving

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

No.:

#1

Size:

< 100 µm

Distribution:

2.9 %

No.:

#1

Size:

> 100 µm

Distribution:

98.1 %

The results of the sieving procedure are shown in the following table:

Measurement	Result
Mass of test item transferred to sieve	12.68 g
Mass of test item passed through sieve	0.37 g
Proportion of test item <100 µm	2.9 %

 

Conclusions:

The proportion of test item having an inhalable particle size of less than 100 µm was determined to be 2.9 %. Therefore, the test item was considered to be essentially non-inhalable.

Executive summary:

The particle size distribution of the test material was evaluated in accordance with OECD Guideline 110 under GLP conditions.

The proportion of a sample that was able to pass through a 100 µm sieve was measured; the proportion of test item having an inhalable particle size of less than 100 µm was determined to be 2.9 %.

Therefore, the test item was considered to be essentially non-inhalable.

Description of key information

The proportion of a sample that was able to pass through a 100 µm sieve was measured; the proportion of test material having an inhalable particle size of less than 100 µm was determined to be 2.9 %.

Therefore, the test material was considered to be essentially non-inhalable.

Additional information

The particle size distribution of the test material was evaluated in accordance with OECD Guideline 110 under GLP conditions. It was assigned a reliability score of 1 in accordance with the principles for assessing data quality as outlined by Klimisch et al (1997).

The proportion of a sample that was able to pass through a 100 µm sieve was measured; the proportion of test material having an inhalable particle size of less than 100 µm was determined to be 2.9 %.

Therefore, the test material was considered to be essentially non-inhalable.