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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo insect germ cell study: gene mutation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data from a report from a recognised body reviewed by a panel of experts. Although there is limited detail on materials and methods included in the publication, the conclusions drawn from the cicads document are considered to be reliable and representative of the mutagenic potential of the substance.
Cross-reference
Reason / purpose for cross-reference:
other: read across: target
Reference
Endpoint:
in vivo insect germ cell study: gene mutation
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reason / purpose for cross-reference:
read-across source
Additional information on results:
Sodium iodate showed no mutagenic activity by the recessive lethal test using Drosophila.
Conclusions:
Interpretation of results: negative

The publication reported that sodium iodate showed no mutagenic activity by the recessive lethal test using Drosophila. No information is provided on experimental materials and methods.
Executive summary:

The publication reported that sodium iodate showed no mutagenic activity by the recessive lethal test using Drosophila. No information is provided on experimental materials and methods.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Final Report on the Safety Assessment of Sodium Iodate
Author:
International Journal of Toxicology
Year:
1995
Bibliographic source:
http://ijt.sageub.com/content/14/3/231
Reference Type:
other: report from a recognised body
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified
Type of assay:
Drosophila SLRL assay

Test material

Constituent 1
Reference substance name:
Sodium iodate
EC Number:
231-672-5
EC Name:
Sodium iodate
Cas Number:
7681-55-2
IUPAC Name:
sodium iodate
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): sodium iodate
- Appearance: white crystalline solid

Test animals

Species:
Drosophila melanogaster
Details on test animals or test system and environmental conditions:
No further information provided on test animals and environmental conditions.

Results and discussion

Additional information on results:
Sodium iodate showed no mutagenic activity by the recessive lethal test using Drosophila.

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative

The publication reported that sodium iodate showed no mutagenic activity by the recessive lethal test using Drosophila. No information is provided on experimental materials and methods.
Executive summary:

The publication reported that sodium iodate showed no mutagenic activity by the recessive lethal test using Drosophila. No information is provided on experimental materials and methods.

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