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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data from a report from a recognised body reviewed by a panel of experts. Although there is limited detail on materials and methods included in the publication, the conclusions drawn from the CICADS document are considered to be reliable and representative of the mutagenic potential of the substance.
Cross-reference
Reason / purpose for cross-reference:
other: read across: target
Reference
Endpoint:
in vitro gene mutation study in bacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
The source material is sodium iodate and the target is sodium periodate. The analogue approach has been used due to the predicted common breakdown products specifically iodine and the sodium in the target material are historically established to have similar properties. Once injested, the materials are anticipated to form the same breakdown products.
Reason / purpose for cross-reference:
read-across source
Key result
Species / strain:
not specified
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Conclusions:
Interpretation of results: negative

The publication reported that sodium iodate showed no mutagenic activity by the Ames test.
Executive summary:

The publication reported that sodium iodate showed no mutagenic activity by the Ames test. No information is provided on experimental materials and methods.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Final Report on the Safety Assessment of Sodium Iodate
Author:
International Journal of Toxicology
Year:
1995
Bibliographic source:
http://ijt.sageub.com/content/14/3/231
Reference Type:
other: report from a recognised body
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
An Ames test was conducted although the publication includes no detail on the materials and methods used in the study.
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Reference substance name:
Sodium iodate
EC Number:
231-672-5
EC Name:
Sodium iodate
Cas Number:
7681-55-2
IUPAC Name:
sodium iodate
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): sodium iodate
- Appearance: white crystalline solid

Results and discussion

Test results
Key result
Species / strain:
not specified
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Any other information on results incl. tables

Sodium iodate showed no mutagenic activity by the Ames test.

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative

The publication reported that sodium iodate showed no mutagenic activity by the Ames test.
Executive summary:

The publication reported that sodium iodate showed no mutagenic activity by the Ames test. No information is provided on experimental materials and methods.

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