Registration Dossier
Registration Dossier
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EC number: 232-197-6 | CAS number: 7790-28-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Data from a report from a recognised body reviewed by a panel of experts. Although there is limited detail on materials and methods included in the publication, the conclusions drawn from the CICADS document are considered to be reliable and representative of the mutagenic potential of the substance.
Cross-reference
- Reason / purpose for cross-reference:
- other: read across: target
Reference
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The source material is sodium iodate and the target is sodium periodate. The analogue approach has been used due to the predicted common breakdown products specifically iodine and the sodium in the target material are historically established to have similar properties. Once injested, the materials are anticipated to form the same breakdown products.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Species / strain:
- not specified
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Conclusions:
- Interpretation of results: negative
The publication reported that sodium iodate showed no mutagenic activity by the Ames test. - Executive summary:
The publication reported that sodium iodate showed no mutagenic activity by the Ames test. No information is provided on experimental materials and methods.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of Sodium Iodate
- Author:
- International Journal of Toxicology
- Year:
- 1 995
- Bibliographic source:
- http://ijt.sageub.com/content/14/3/231
- Reference Type:
- other: report from a recognised body
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- An Ames test was conducted although the publication includes no detail on the materials and methods used in the study.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium iodate
- EC Number:
- 231-672-5
- EC Name:
- Sodium iodate
- Cas Number:
- 7681-55-2
- IUPAC Name:
- sodium iodate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): sodium iodate
- Appearance: white crystalline solid
Constituent 1
Results and discussion
Test results
- Key result
- Species / strain:
- not specified
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Any other information on results incl. tables
Sodium iodate showed no mutagenic activity by the Ames test.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
The publication reported that sodium iodate showed no mutagenic activity by the Ames test. - Executive summary:
The publication reported that sodium iodate showed no mutagenic activity by the Ames test. No information is provided on experimental materials and methods.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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