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EC number: 223-829-1
CAS number: 4090-51-1
In a test on hydrolysis as a function of pH significant hydrolysis was only observed at pH 9 and elevated temperature of 50°C. Half-lives and rate constants determined at pH 9 and more moderate temperatures of 20 and 30 °C were not significantly non-zero.
Hydrolysis as a function of pH was
determined for the submission substance according to OECD Guideline No.
111 and Council Regulation (EC) No. 440/2008, Method C.7 for the test
item (compliant to GLP, RL1).
In the preliminary test no significant
elimination was observed at pH 4, from which a half-life of > 1 year
could be assumed at this pH for environmental typical temperatures.
Therefore, the advanced test was conducted at pH 7 and 9 but not pH 4.
The advanced test was conducted with a test item concentration of
0.7 mg/L in buffer solutions at pH 7 and 9 and temperatures of 20, 30
and 50 °C, respectively. At the pH 7 / 50 °C test condition no
degradation was observed after approx. 200 h, therefore the test item
was considered as hydrolytically stable under these condition and a
half-life of > 1 year could be assumed for environmental typical
temperatures. Only at the test condition pH 9 / 50 °C significant
hydrolysis of the test item was observed. At the other two test
conditions (20 and 30 °C of the same pH value) the reaction rate
constants and half-lives could not be securely determined by employing
the methods of the test guidelines and should only be seen as estimation
with a high degree of uncertainty.
The following pseudo first order
half-lives for the pH 9 test condition were calculated from the analysed
20°C: 166 days (not significantly
non-zero); 30°C: 195 days (not significantly non-zero); 50°C:
2.99 days (significantly non-zero).
Because no hydrolysis could be observed at environmentally relelvant
temperatures, in line with OECD 111 no identification of transformation
products was performed.
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