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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1978
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: OECD SIDS evaluation: Guideline study

Data source

Reference
Reference Type:
publication
Title:
Acute Dermal Toxicity Study in Rabbits
Author:
Rinehart, WE
Year:
1978
Bibliographic source:
Toxicological Resources Unit, Bio/dynamics Inc., 1978.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EPA 16 CFR 1500.40
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
sodium carbonate monohydrate
IUPAC Name:
sodium carbonate monohydrate
Details on test material:
TS-Freetext:
SOURCE: Not reported.
PURITY: Not reported.
IMPURITY/ADDITIVE/ETC.: Not reported.

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified

Administration / exposure

Vehicle:
water
Doses:
2000 mg/kg bw as a 1000 mg/ml aqueous slurry.
No. of animals per sex per dose:
6

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
None

Any other information on results incl. tables

RS-Freetext:
MORTALITY: No deaths occurred during the experiment.
CLINICAL SIGNS: 3/6 animals gained weight during the 14 days
the experiment lasted.  3/6 animals lost weight or did not
gain weight. Well-defined to severe erythema and slight to
severe oedema were observed in all six animals at the
24-hour dermal observations. The severity of the lesions did
not vary significantly between the animals with abraded or
non-abraded skin.  Lethargy and hypernea were observed in
each animal during the first 24 hrs following compound
administration.
NECROPSY FINDINGS: Not reported.
POTENTIAL TARGET ORGANS: Skin.
SEX-SPECIFIC DIFFERENCES: Not reported.

Applicant's summary and conclusion