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EC number: 934-716-8 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD SIDS evaluation: Guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Dermal Toxicity Study in Rabbits
- Author:
- Rinehart, WE
- Year:
- 1 978
- Bibliographic source:
- Toxicological Resources Unit, Bio/dynamics Inc., 1978.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA 16 CFR 1500.40
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- sodium carbonate monohydrate
- IUPAC Name:
- sodium carbonate monohydrate
- Details on test material:
- TS-Freetext:
SOURCE: Not reported.
PURITY: Not reported.
IMPURITY/ADDITIVE/ETC.: Not reported.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Vehicle:
- water
- Doses:
- 2000 mg/kg bw as a 1000 mg/ml aqueous slurry.
- No. of animals per sex per dose:
- 6
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None
Any other information on results incl. tables
RS-Freetext:
MORTALITY: No deaths occurred during the experiment.
CLINICAL SIGNS: 3/6 animals gained weight during the 14 days
the experiment lasted. 3/6 animals lost weight or did not
gain weight. Well-defined to severe erythema and slight to
severe oedema were observed in all six animals at the
24-hour dermal observations. The severity of the lesions did
not vary significantly between the animals with abraded or
non-abraded skin. Lethargy and hypernea were observed in
each animal during the first 24 hrs following compound
administration.
NECROPSY FINDINGS: Not reported.
POTENTIAL TARGET ORGANS: Skin.
SEX-SPECIFIC DIFFERENCES: Not reported.
Applicant's summary and conclusion
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