Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The sensitising potential of Zorgol 48 (1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. Residues) can be assessed based on the results of a local lymph node test (OECD 429, EU B.42).

 

In a local lymph node assay, adult female CBA/CaOlaHsd mice (4 animals per group) were tested with Zorgol 48 using concentrations of 25, 50, and 100% (vehicle acetone/olive oil 4:1).

 

No effects were noticed on body weight development and no signs of systemic toxicity were seen. No skin irritation was observed at the application sites for any test concentration.

 

Incorporation of radioactivity in lymph nodes was increased for all test concentrations over controls (SI 2.02, 4.83, and 5.75 respectively).EC3was determined to be33.7%. In this study,Zorgol 48is aweak dermal sensitizer(Vogel/Laus, 2010).


Migrated from Short description of key information:
In a local lymph node assay, Zorgla 48 was shown to be a weak dermal sensitizer

Justification for classification or non-classification

Based on the results of a local lymph node test, Zorgol 48 (1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. Residues) is classified as sensitising according to Directive 67/548/EEC and as skin sensitizer (Category 1) according to Regulation (EC) No 1272/2008.