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Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2008-07-31 to 2008-09-02
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study is regarded as reliable without restrctions because it was conducted in accordance with GLP regulation and guideline.
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
1993
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
capillary method
Key result
Melting / freezing pt.:
>= 45 - <= 49 °C
Atm. press.:
101.3 kPa
Decomposition:
no
Sublimation:
no

Results

 

Using a linear heating rate of 0.5 °C/min the melting range of the test item was found to be 45 – 49 °C (318 – 322 K).

 

Table 1. Measured temperatures corresponding to the melting (temp. 1./2./3.) of the test item (three experiments (I, II, III) with three parallel samples each (1, 2, 3)

 

Measured Temperatures during the Main Study (°C)

 

I /1

I /2

I /3

II /1

II /2

II /3

III /1

III /2

III /3

Mean

Beginning of melting

Temp. 1.

44.8

44.8

44.8

44.7

44.7

44.7

44.8

*

44.8

45

Temp. 2.

46.8

46.8

46.8

46.7

46.7

46.7

46.7

46.7

46.7

47

Final stage melting

Temp. 3.

48.6

48.6

48.6

48.4

48.4

48.4

48.6

48.5

48.6

49

* recording error

Conclusions:
Using a linear heating rate of 0.5 °C/min the melting range of the test item was found to be 45 – 49 °C (318 – 322 K) at 101.3 kPa.
Executive summary:

A study according to OECD 102 and EU Method A.1 was performed to determine the melting point of the test item. The capillary method was used. Using heating rate of 0.5 °C/min three measurements with 3 replicates each were conducted. The test item melting range was determined to be 45 - 49 °C at 101.3 kPa.

Description of key information

Using the capillary method, the melting range of the test item was found to be 45 – 49 °C (318 – 322 K) at 101.3 kPa.

Key value for chemical safety assessment

Additional information

A study according to OECD 102 and EU Method A.1 was performed to determine the melting point of the test item. The capillary method was used. Using heating rate of 0.5 °C/min three measurements with 3 replicates each were conducted. The test item melting range was determined to be 45 - 49 °C at 101.3 kPa.

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