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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2015-02-24 to 2015-02-25
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study is regarded as reliable without restrictions because it was conducted in compliance with GLP regulation and guideline.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
adopted 23. Mar. 2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
dated 24 August 2009
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Key result
Temp.:
20 °C
Vapour pressure:
0.071 Pa
Temp.:
25 °C
Vapour pressure:
0.083 Pa

The measured values for temperature and vapour pressure were evaluated as follows:

Evaluation of Calculated Values

Parameter

T

P

1/T

log P

Unit

K

Pa

1/K

log Pa

Values

298.2

8.43E-02

3.3535E-03

-1.0744

318.2

1.43E-01

3.1427E-03

-0.8460

338.2

2.51E-01

2.9568E-03

-0.5995

A graph with log P vs. 1/T was plotted. Since the values were correlated by a linear relation, the data could be fitted by linear regression.

Parameters of Linear Regression

Parameter

Value

Slope

-1194.7

Intercept

2.9246

Correlation Coefficient r

-0.9983

Coefficient of Determination r2

0.9966

The following vapour pressures were determined experimentally and considered as valid:

T

T

P

Stand. Dev. P

RSD P

°C

K

Pa

Pa

%

25.0

298.2

8.43E-02

4.99E-04

0.6%

45.0

318.2

1.43E-01

2.53E-02

17.7%

65.0

338.2

2.51E-01

1.55E-02

6.1%

Conclusions:
The vapour pressure of the test item was determined to be 0.0707 Pa at 20 °C and 0.0827 Pa at 25 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at three different temperatures (25, 45 and 60 °C) using the effusion method (weight loss). All measured values showed good reproducibility, giving relative standard deviations of less than 25 %, and perfect correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated to be 0.0707 Pa at 20 °C and 0.0827 Pa at 25 °C, respectively.

Description of key information

The vapour pressure of the test item was determined to be 0.0707 Pa at 20 °C and 0.0827 Pa at 25 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0.071 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at three different temperatures (25, 45 and 60 °C) using the effusion method (weight loss). All measured values showed good reproducibility, giving relative standard deviations of less than 25 %, and perfect correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated to be 0.0707 Pa at 20 °C and 0.0827 Pa at 25 °C, respectively.

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