Registration Dossier
Registration Dossier
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EC number: 800-426-4 | CAS number: 1373883-45-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
NOELR (72h) >= 1000 mg/L (OECD 201, Scenedesmus subspicatus); read-across
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity to algae of Fatty acids, C18 unsaturated, trimers, hydrogenated are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5, a read across to the structurally similar substances Fatty acids, C18-unsatd., trimers (CAS No. 68937-90-6) and Fatty acids, C16-18 and C18-unsatd., branched and linear (CAS 68955-98-6) was conducted. Further justification is given within the endpoint summary 6.1 and within the analogue justification in Section 13.
The key study conducted with Fatty acids, C18-unsatd., trimers (CAS No. 68937-90-6) was performed according to ISO 10253 and GLP. The marine test organism Skeletonema costatum was exposed to the test substance at loading rates of 100, 180, 320, 560 and 1000 mg/L for 72 hours (Källqvist, 2004). The test solutions were prepared as water accommodated fractions (WAF). As the treatment had no significant effect on algal growth, the NOELR was reported to be ≥ 1000 mg/L.
The key study conducted with Fatty acids, C16-18 and C18-unsatd., branched and linear (CAS 68955-98-6) was performed as a limit test according to OECD 201. The test organism Scenedesmus subspicatus was exposed to the test substance at a loading rate of 1000 mg/L for 72 hours (Sewell, 1994). The test solutions were prepared as water accommodated fractions (WAF). As the treatment had no significant effect on algal growth, the NOELR was reported to be ≥ 1000 mg/L.
Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1, it can be concluded that no toxicological effects on algae are expected up to the limit of water solubility (0.001 mg/L) for Fatty acids, C18 unsaturated, trimers, hydrogenated.
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