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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V, B3
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4,6-bis(octylthiomethyl)-o-cresol
EC Number:
402-860-6
EC Name:
4,6-bis(octylthiomethyl)-o-cresol
Cas Number:
110553-27-0
Molecular formula:
C25H44OS2
IUPAC Name:
4,6-bis(octylthiomethyl)-o-cresol

Test animals

Species:
other: Albino Rats, Tif: RAlf (SPF) hybrides of Rll 1

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: liquid substance, use undiluted
Duration of exposure:
24h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Feale: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels: sedation, dyspnea, exophtalmos, ruffled fur and ventral and curved body position.
Gross pathology:
Effects on organs: no deviations from normal morphology were found on autopsy.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to test results on rats and applying the EU Criteria, the substance is considered to be nontoxic.
Executive summary:

The LD50 won't be considered as use descriptor for DNEL derivation due to the uncertainty of this kind of derivation