Registration Dossier
Registration Dossier
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EC number: 807-374-1 | CAS number: 2540-36-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- sodium O-isopentyl dithiocarbonate
- Cas Number:
- 2540-36-5
- Molecular formula:
- C6H11OS2.Na
- IUPAC Name:
- sodium O-isopentyl dithiocarbonate
- Test material form:
- other: water solution
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- water
- Amount / concentration applied:
- 0.1 ml/eye as water solution
- Observation period (in vivo):
- Observation were made after 1h, 24, 48 hours and then after 7 days
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- was introduced into the conjunctival sacs of the right eye
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Time point:
- other: 1 h
- Score:
- 68
- Irritation parameter:
- overall irritation score
- Time point:
- other: 24 h
- Score:
- 70
- Irritation parameter:
- overall irritation score
- Time point:
- other: 48 h
- Score:
- 70
- Irritation parameter:
- other: IIPO
- Time point:
- other: 7 days
- Score:
- 70
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Conclusions:
- Sodium isopentyl xanthate should be consider as seriously injured substance of the rabbit eyes.
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