1H-Pyrazolo[3,4-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-, ethyl ester

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental Starting Date: 25 April 2014 Experimental Completion Date: 03 June 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Decomposition:

yes

Decomp. temp.:

>= 304.9 °C

Remarks on result:

other: The test item has been determined to decompose from 304.9 °C (578.0 K) at 100.7 to 100.9 kPa. As the test item decomposed, no value for boiling temperature could be determined.

Results

Thermograms for Determinations 1, 2 and 3 are shown in Attachment 2.

Thermographic Data is shown in the following table:-

Table 3.4– Thermographic Data

 

Thermal Event	Interpretation		Temperature
			Determination 1		Determination 2		Determination 3
			ºC	K	ºC	K	ºC	K
Endotherm	Melting		191.70	464.9	191.50	464.7	191.68	464.8
Exotherm	Decomposition	Peak Start	305.20	578.4	304.70	577.9	304.70	577.9
		Onset	345.50	618.7	345.51	618.7	345.30	618.5

 

Atmospheric pressure             :          Determination 1 and 2:          100.9 kPa

                                                           Determination 3:                   100.7 kPa

 

Overall result: The test item decomposed from 304.9 °C (578.0 K).

Conclusions:

The test item has been determined to decompose from 304.9 °C (578.0 K) at 100.7 to 100.9 kPa. As the test item decomposed, no value for boiling temperature could be determined.

Executive summary:

The determination was carried out by differential scanning calorimetry, using a procedure designed to be compatible with Method A2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Instrument                  :          Mettler Toledo DSC822e Differential Scanning Calorimeter (DSC) incorporating ThermoHaake Cooler EK45/MT.

 

Sample crucibles        :          Aluminum crucible with lid.

 

Reference crucible     :          Empty aluminum crucible with lid.

 

Test conditions           :          The test was performed in an air and a nitrogen atmosphere.

Conclusion

The test item has been determined to decompose from 304.9 °C (578.0 K) at 100.7 to 100.9 kPa. As the test item decomposed, no value for boiling temperature could be determined.

Description of key information

The determination was carried out by differential scanning calorimetry, using a procedure designed to be compatible with Method A2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

The test item has been determined to decompose from 304.9 °C (578.0 K) at 100.7 to 100.9 kPa.  As the test item decomposed, no value for boiling temperature could be determined.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

304.9 °C