Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0 mg/L
Assessment factor:
1
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.001 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor
PNEC marine water (intermittent releases):
0 mg/L

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
10 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.014 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.001 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0 mg/kg soil dw
Assessment factor:
10
Extrapolation method:
assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
PNEC oral
PNEC value:
33.83 mg/kg food
Assessment factor:
30

Additional information

Conclusion on classification

Environmental fate and pathways

Biodegradation

Not readily biodegradable (0% in 28 d, OECD 301 F)

DT50 (water) > 1000 d (20 °C, OECD 309)

DT50 (water-sediment) = 127 – 365 d (20 °C, OECD 308)

DT50 (anaerobic water-sediment) > 365 d (20 °C, OECD 308)

Bioaccumulation

log Kow (pH 7)= 2.8 / 3.7 (OECD 117/ OECD 107)

BCF steady state = 11 (whole body dw, normalized to 6% lipid content, OECD 305, L. macrochirus)

Aquatic short-term toxicity

Freshwater

Fish

LC50 (96 h) = 0.32 mg a.i./L (arithm. mean measured, OECD 203, L. macrochirus)

Aquatic invertebrates

EC50 (48 h) > 9.88 mg a.i./L (arithm. mean measured, OECD 202, D. magna)

Algae

ErC50 (72 h) = 0.112 mg a.i./L (measured initial, OECD 201, P. subcapitata)

 

Saltwater

Fish

LC50 (96 h) = 0.96 mg a.i./L (arithm. mean measured, OECD 203, C. variegatus)

Aquatic invertebrates

LC50 (96 h) = 1.5 mg a.i./L (arithm. mean measured, EPA OPPTS 850.1035, A. bahia)

Algae

ErC50 (72 h) = 0.064 mg a.i./L (arithm. mean measured, OECD 201, S. costatum)

Other aquatic invertebrates

LC50 (96 h) > 2 mg a.i./L (arithm. mean measured, EPA OPPTS 850.1025, C. virginica);

EC50 (96 h) 1 mg a.i./L (shell deposition, arithm. mean measured, EPA OPPTS 850.1025, C. virginica)

 

Aquatic long-term toxicity

freshwater

Fish

NOEC (35 d) = 0.46 mg a.i./L (arithm. mean measured, OECD 210, P. promelas)

Aquatic invertebrates

NOEC (21 d) = 0.34 mg a.i./L (arithm. mean measured, OECD 211, D. magna)

NOEC saltwater (28 d): 0.12 mg a.i./L (measured, EPA OPPTS 850.1350, Americamysis bahia)

Algae

NOErC (72 h) = 0.02 mg a.i./L (measured initial, OECD 201, P. subcapitata)

Aquatic plants other than algae

NOEC (70 d) = 0.00001 mg a.i./L (nominal, mesocosm, Lemna gibba, Spirodela polyrhiza)

Saltwater

Algae

NOErC (72 h) = 0.0051 mg a.i./L (arithm. mean measured, OECD 201, S. costatum)

 

Conclusion on CLP

Based on the available data summarized above, Indaziflam (CAS 950782-86-2) is classified and labelled for environmental hazards as Aquatic Acute 1 (H400) and Aquatic Chronic 1 (H410), according to the latest consolidated version of Regulation (EC) No 1272/2008 and all further amendments (ATPs).

M-factor acute: 10

M-factor chronic: 10000