Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 903-816-3 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the current O.E.C.D. Testing Guideline without GLP compliance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Chloropropene Screening Information Dataset
- Author:
- O.E.C.D.
- Year:
- 1 996
- Bibliographic source:
- O.E.C.D. Environment Directorate ChemPortal
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-chloropropene
- EC Number:
- 203-457-6
- EC Name:
- 3-chloropropene
- Cas Number:
- 107-05-1
- Molecular formula:
- C3H5Cl
- IUPAC Name:
- 3-chloroprop-1-ene
- Details on test material:
- As per the IUCLID5 Sections 1.1. - 1.4. for 3-chloropropene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 gm at 100%.
- Duration of treatment / exposure:
- 4 hr
- Observation period:
- 72 hr
- Number of animals:
- 2
- Details on study design:
- Exposure was semi-occlusive for approximately 4 hr. Following the exposure the sites were washed with Lutrol and Lutrol 50 % (Lutrol = PEG 400).
Scoring ws by the method of Draize.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hr.
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hr
- Irritant / corrosive response data:
- A maximum score of 1 for erythema was observed at 60 minutes and 24 hr post-exposure in both animals.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test substance 3-chloropropene was not irritating to rabbit skin following a 4 hr semi-occlusive exposure. Similar results are expected for AC Light ends.
- Executive summary:
Test substance 3 -chloropropene was assessed for dermal irritation potential in am O.E.C.D. Testing Guideline 404 "Acute Dermal Irritation/Corrosion" study in two rabbits. The mean PII was reported to be 0.33. Therefore, the test substance 3-chloropropene was not irritating to rabbit skin following a 4 hr semi-occlusive exposure. Similar results are expected for AC Light ends.
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