Reaction mass of 1,3-dichloropropene and 2-chloropropane and 2-chloropropene and 3-chloropropene

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to O.E.C.D. Testing Guideline 405, "Acute eye Irritation/Corrosion" without GLP compliance.

Data source

Reference

Reference Type:

publication

Title:

Chloropropene Screening Information Dataset

Author:

O.E.C.D.

Year:

1996

Bibliographic source:

O.E.C.D. Environment Directorate ChemPortal

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

yes

Remarks:

Approximately half (0.05 mL) of the testing guideline recommended volume was applied.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-chloropropene

EC Number:

203-457-6

EC Name:

3-chloropropene

Cas Number:

107-05-1

Molecular formula:

C3H5Cl

IUPAC Name:

3-chloroprop-1-ene

Details on test material:

As per the IUCLID5 Sections 1.1. - 1.4. for 3-chloropropene.

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

No data

Test system

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

The amount instilled was ca. 42 mg, or 0.0447 mL at a concentration of 100 %.

Duration of treatment / exposure:

72 hr , no washout.

Observation period (in vivo):

72 hr

Number of animals or in vitro replicates:

2, one of each sex

Details on study design:

Scoring system was according to Kay and Calandra (Kay, J.H. & Calandra, J.C. (1962) Interpretation of eye irritation tests. J. Soc. Cosmet. Chem. 13, 281–289. ).

Results and discussion

In vivo

Results

Irritation parameter:

conjunctivae score

Basis:

animal #1

Time point:

other: 60 minutes after dosing.

Score:

1

Max. score:

1

Reversibility:

fully reversible within: 24 hr.

Remarks on result:

other: Observation was in only one animal.

Irritant / corrosive response data:

A conjunctival redness score of 1 observed 60 minutes after treatment in one animal was the only evidence of an irritant effect. This finding was fully reversable after 24 hr.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

3-Chloropropene is not irritating to the rabbit eye.

Executive summary:

3 -Chloropropene, a structural analog for AC Light Ends, was evaluated for eye irritation potential by an O.E.C.D. 405 "Acute Eye Irritation/Corrosion" Testing guideline study. A conjuctival redness score of 1 was observed in one animal 60 minutes after treatment. This finding was fully reversable after 24 hr. Therefore, 3-Chloropropene is not irritating to the rabbit eye under the conditions of the study. This finding is believed to be representative of AC Light Ends.