Registration Dossier
Registration Dossier
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EC number: 235-819-4 | CAS number: 12777-87-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Sulphuric acid, compound with graphite is an inorganic solid, consisting of natural graphite and variable amounts of intercalated sulphuric acid.
Graphite is a naturally occurring solid substance which is insoluble in water. Due to its physico-chemical properties it is not systemically and biologically available and does not cross biological membranes. In the aquatic compartment it can be considered as an inert substance.
The intercalated sulphuric acid is partially leached out by water and dissociated into the environmentally ubiquitous sulphate and hydronium ions. Due to their ionic character, they do not cross biological membranes. Sulphate is a normal biological constituent of the body, a normal biological metabolite and a degradation product of sulphur-containing amino-acids. An excessive level of sulphate is excreted in the urine; furthermore the body electrolyte pool of this anion is large and it is therefore unlikely that a long-term uptake significantly modify the normal body load.
Due to its physico-chemical characteristics (does not cross biological membranes) it can be inferred that the substance is unlikely to be taken up into the blood stream because of its low bioavailability. Therefore, sulphuric acid, compound with graphite is not systemically available, which is further supported by oral and dermal studies conducted with this substance (see chapters 7.2.1, 7.2.3 of the IUCLID dossier).
Against this background, it is considered unnecessary to perform laboratory studies on basic toxicokinetics with sulphuric acid,
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
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