Reaction products of fatty acid chlorides, C8-12 (even numbered) with glycine and sodium hydroxide

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2008-08-21 to 2008-08-25

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Analytical monitoring:

yes

Details on sampling:

0, 96h

Vehicle:

no

Details on test solutions:

direct weighing, limit test at 100 mg/L test item (29.8 mg/L a.i.)

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 h

Hardness:

Total Hardness 59 mg/L as CaCO3

Test temperature:

22.3 degree C

pH:

7.23-7.62

Dissolved oxygen:

Oxygen saturation 95-100%

Nominal and measured concentrations:

nominal 100 mg/L test item concentration, 16.6 mg/L DOC of test media

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

> 29.8 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

29.8 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

29.8 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

> 100 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

100 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

100 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Executive summary:

In this static limit test according OECD 203 the test item Hostapon SG (a.i content of solution 29.8% ww) did not cause any effects to zebrafish after 96h when tested with a nominal concentration of 100 mg/L (29.8 mg/L a.i.). LC0 and NOEC are 100 mg/L (29.8 mg/L a.i.). LC100 is > 100 mg/L (> 29.8 mg/L a.i.).

Validity criteria on Oxygen saturation (>= 60%) and Mortality in the control (0%) were met.

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

2008-08-21 to 2008-08-25

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

see Rationale and Justification for the Analogue Read-Across Approach used for the Registration of Sodium Lauroyl Glycinate (SLG) (Chapter 13)

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Analytical monitoring:

yes

Details on sampling:

0, 96h

Vehicle:

no

Details on test solutions:

direct weighing, limit test at 100 mg/L test item (29.8 mg/L a.i.)

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 h

Hardness:

Total Hardness 59 mg/L as CaCO3

Test temperature:

22.3 degree C

pH:

7.23-7.62

Dissolved oxygen:

Oxygen saturation 95-100%

Nominal and measured concentrations:

nominal 100 mg/L test item concentration, 16.6 mg/L DOC of test media

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

> 29.8 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

29.8 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

29.8 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC100

Effect conc.:

> 100 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

100 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

100 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Executive summary:

In this static limit test according OECD 203 the test item Hostapon SG (a.i content of solution 29.8% ww) did not cause any effects to zebrafish after 96h when tested with a nominal concentration of 100 mg/L (29.8 mg/L a.i.). LC0 and NOEC are 100 mg/L (29.8 mg/L a.i.). LC100 is > 100 mg/L (> 29.8 mg/L a.i.).

Validity criteria on Oxygen saturation (>= 60%) and Mortality in the control (0%) were met.

Description of key information

In this static limit test according OECD 203 the test item Hostapon SG (a.i content of solution 29.8% ww) did not cause any effects to zebrafish after 96h when tested with a nominal concentration of 100 mg/L (29.8 mg/L a.i.). LC0 and NOEC are 100 mg/L (29.8 mg/L a.i.). LC100 is > 100 mg/L (> 29.8 mg/L a.i.).

Validity criteria on Oxygen saturation (>= 60%) and Mortality in the control (0%) were met.