Registration Dossier
Registration Dossier
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EC number: 940-223-9 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
No studies on the EC substance [940-223-9] itself are available. A read-across approach using the very close structural analogue [938-147-6] Fatty acid chlorides, C8-14 (even numbered), reaction products with glycine (Public name: Sodium cocoyl glycinate (SCG)) as source substance was chosen. Justification for read across is given in the document attached in IUCLID Section 13.
Sodium cocoyl glycinate (SCG) is an anionic surfactant which forms Ca and Mg salts with very low water solubility which results in precipitation of SCG. This is a considerable issue when testing SCG in aqueous solution with high total hardness. As for Daphnia a minimum water hardness is especially important for the chronic test to achieve sufficient reproduction, analytical substance recovery is good at test start but is in most case below the LOQ at the end of the tested intervall. For establishing the average substance concentration it is assumed that the half-nominal concentration is representative for the test intervall (100% (=nominal) at start of test intervall, 0% at the end of the test intervall results in overall 50% (half-nominal). The formation of Mg and Ca with low water solubility is less pronounced in fish and algae test as the test can be run at lower water hardness.
One acute Daphnia test was run with EDTA as complexing agent for Ca2+ and Mg2+ reducing the ions to a level that no SCG was precipitated. In this case the substance recovery over the test intervall was within the acceptable limits e.g. >70%. Unfortunately this was not applicable to the chronic daphnia test as otherwise reproduction would have been inhibited.
The table below summarizes the Aquatic ecotoxicity data for SCG (active ingredient a.i.):
| Test type | Guideline | Species | Effect | Value (mg/L) a.i. | Remark |
| Acute fish | OECD 203 | Danio rerio | LC50 (96h)NOEC (96h) | > 29.8 | 29.8 mg/L a.i.was highest tested concentration |
| Acute daphnia | OECD 202 | Daphnia magna | EC50 (48h) | 6.5 | with EDTA |
| Algae | OECD 201 | Scenedesmus susp. | ErC50 (72h) | 61.6 | |
| Bacteria | OECD 209 | Municipal sludge | EC50 (3h) | 791 | |
| Chronic daphnia | OECD 211 | Daphnia magna | NOEC (21d) Reprod | 4 | |
| Algae | OECD 201 | Scenedesmus susp. | ErC10 (72h) | 21.7 |
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