Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-017-2 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis of the test item is rapidly completed. Neither the determination of hydrolysis rates according to OECD TG 111 (2004) nor the detection of hydrolysis products was possible.
In the filtrate of the solubility test no test item could be detected. The precipitating solid is not identical with the test item. Only traces of isocyanates could be found (Currenta, 2010a).
Toluene diisocyanate undergoes heterogeneous interaction with water whereas the kinetics and the product distribution strongly depends on the degree of agitation, the surface area of the substance and the stoichiometric conditions. It was shown that toluene diamine and insoluble polyurea were amongst others formed as reaction products, but only with good agitation and low loadings, TDA will be the main reaction product. Otherwise, insoluble polyurea compounds are formed. (Yakabe, 1999)
Key value for chemical safety assessment
Additional information
No test conditions could be found enabling the performance of a hydrolysis study for the substance according to OECD TG 111 (2004).
- As the test item is characterized by the presence of isocyanate groups, hydrolysis reactions have to be assumed. Although it was not possible to separate between the insolubility effect and a hydrolysis it has to be assumed that hydrolysis occurs immediately within a few hours after contact with water.
- The test item is not sufficiently soluble in water and precipitates immediately when mixed with water.
-The test item is a No-Longer-Polymer (NLP). As it consists of different fractions, several peaks were observed in the chromatograms of the test item in organic solutions. The response is therefore spread over few peaks which decreases the sensitivity of the analytical method hampering the detection of peaks in the required concentration range. Additionally, a distinct hydrolysis behaviour of the different fractions has to be assumed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
