Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.1 mg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
1 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.01 mg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
10 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.372 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.037 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.015 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

According to Article 13 of Regulation (EC) No. 1907/2006 "General Requirements for Generation of Information on Intrinsic Properties of substances", Information on intrinsic properties of substances may be generated by means other than tests e.g. from information from structurally related substances (grouping or read-across), provided that conditions set out in Annex XI are met.

Annex XI, "General rules for adaptation of this standard testing regime set out in Annexes VII to X” states that “substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances. This avoids the need to test every substance for every endpoint”.

Since data on the toxicity of 6-methyl-2-oxoperhydropyrimidin-4-yl urea are not available for all aquatic organisms the assessment of the aquatic toxicity of the substance is partly based on information on the structurally related substance N,N''-(isobutylidene)diurea (CAS No 6104-30-9).

Degradation
Biodegradation in water: 85.6% (ThCO2) in 28 days (OECD 301B)

Bioaccumulation
Log Kow: -1.34 (OECD 207)

Acute toxicity
Fish: Oncorhynchus mykiss LC50 (96 h): >1000 mg/L (OECD 203); read across

Aquatic invertebrates: Daphnia magna EC50 (48 h): >100 mg/L (Directive 93/32/EEC)

Algae: Scenedesmus subspicatus EC50 (96 h): > 500 mg/L (DIN 38412, part 9); read across

 

Chronic toxicity
No data available

CLP

6-methyl-2-oxoperhydropyrimidin-4-yl urea is readily biodegradable and has no potential to bioaccumulate. The substance is considered to be not acutely toxic to fish, aquatic invertebrates or algae. Data on chronic toxicity are not available. However, due to the ready biodegradability, expected environmental fate and the data on acute toxicity a chronic toxicity is not expected. Therefore, 6-methyl-2-oxoperhydropyrimidin-4-yl urea does not need to be classified and labelled as environmental hazardous according to the Regulation (EC) No 1272/2008 and the Regulation (EU) No 286/2011 (2nd ATP).

DSD

6-methyl-2-oxoperhydropyrimidin-4-yl urea is readily biodegradable and has no potential to bioaccumulate. The substance is considered to be not acutely toxic to fish, aquatic invertebrates or algae. Therefore, 6-methyl-2-oxoperhydropyrimidin-4-yl urea does not need to be classified and labelled as environmental hazardous according to Directive 67/548/EEC.