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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

No toxic effects on fish. LC50 (96 h): > 1000 mg/L for Oncorhynchus mykiss (OECD 203)

Key value for chemical safety assessment

Additional information

Data on the short-term toxicity of 6-methyl-2-oxoperhydropyrimidin-4-yl urea to fish are not available. Thus the evaluation of short-term toxicity of the substance to fish is based on studies conducted with a structurally similar analogue substance, for which data is available, N,N''-(isobutylidene)diurea (CAS No. 6104-30-9) as part of a read across approach. This is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the analogue justification section 13. A study following OECD guideline 203 is available for N,N''-(isobutylidene)diurea (CAS No. 6104-30-9) (BASF AG, 1986). The test was conducted with Rainbow trout (Oncorhynchus mykiss) in a static test system. The fish were exposed to the test substance for 96 hours. At test termination a LC50 >1000 mg/L (NOEC: 1000 mg/L) based on nominal test substance concentrations was determined.