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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

No toxic effects on aquatic algae. EC50 (96 h): > 500 mg/L for Scenedesmus subspicatus (DIN 38412, part 9)

Key value for chemical safety assessment

Additional information

Since no studies on algal toxicity are directly available for 6-methyl-2-oxoperhydropyrimidin-4-yl urea (CAS No. 1129-42-6), the assessment of algal toxicity was based on studies conducted with a structurally similar analogue substance, for which data is available, ANALOGUE N,N''-(isobutylidene)diurea (CAS No 6104-30-9) as part of a read across approach. This is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the analogue justification section 13.

The short-term toxicity of N,N''-(isobutylidene)diurea (CAS No 6104-30-9) was tested using Desmodesmus subspicatus (cited as: Scenedesmus subspicatus) as test organisms (BASF AG, 1987). In the test conducted in compliance with DIN 38412, part 9 the algae were exposed to the test substance for 96 hours. Based on the growth rate of algae an EC50 > 500 mg/L was determined. The effect concentration is based on the nominal test concentration.