Registration Dossier
Registration Dossier
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EC number: 236-826-5 | CAS number: 13499-05-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study not performed according to GLP, no details provided regarding experimental design (doses, number of animals) and observation only for 7 days, but data are well documented and scientifically acceptable.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicologic and pharmacologic effects of hafnium salts
- Author:
- Haley TJ, Raymond K, Komesu N, Upham HC
- Year:
- 1 962
- Bibliographic source:
- Toxicology and applied pharmacology 4, 238-246
Materials and methods
- Principles of method if other than guideline:
- No details available on method. The acute toxicity was investigated by intraperitoneal route for 7 days.
- GLP compliance:
- no
- Test type:
- other: intraperitoneal LD50
Test material
- Reference substance name:
- Hafnyl chloride (HfOCl2)
- IUPAC Name:
- Hafnyl chloride (HfOCl2)
- Details on test material:
- hafnium chloride 98.5% purity, no other details
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- male
Administration / exposure
- Route of administration:
- other: intraperitoneal
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- total number of animals: 86
- Control animals:
- not specified
- Details on study design:
- observation of the animals for 7 days after the administration of hafnyl chloride
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 112 mg/kg bw
- Based on:
- not specified
- 95% CL:
- 93.3 - 134.4
- Mortality:
- The first deaths occurred within 24 hours but the peak was not reached until 48 hours. A few animals survived until the sixth day of the study.
- Clinical signs:
- other: The symptoms of acute toxicity were immediate urination and lethargy.
Applicant's summary and conclusion
- Executive summary:
The intraperitoneal LD50was determined on 86 male CF-1 mice and was found to be 112 mg/kg (93.3-134.4) for hafnyl chloride (HfOCl2), for 7 days. The symptoms of acute toxicity were immediate urination and lethargy. The first deaths occurred within 24 hours but the peak was not reached until 48 hours. A few animals survived until the sixth day of the study.
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