Hafnium tetrachloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: study not performed according to GLP, no details provided regarding experimental design (doses, number of animals) and observation only for 7 days, but data are well documented and scientifically acceptable.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

The toxicologic and pharmacologic effects of hafnium salts

Author:

Haley TJ, Raymond K, Komesu N, Upham HC

Year:

1962

Bibliographic source:

Toxicology and applied pharmacology 4, 238-246

Materials and methods

Principles of method if other than guideline:

No details available on method. The acute toxicity was investigated by intraperitoneal route for 7 days.

GLP compliance:

no

Test type:

other: intraperitoneal LD50

Test material

Test material information

Constituent 1

Reference substance name:

Hafnyl chloride (HfOCl2)

IUPAC Name:

Hafnyl chloride (HfOCl2)

Details on test material:

hafnium chloride 98.5% purity, no other details

Test animals

Species:

mouse

Strain:

CF-1

Sex:

male

Administration / exposure

Route of administration:

other: intraperitoneal

Vehicle:

not specified

Details on oral exposure:

no data

Doses:

no data

No. of animals per sex per dose:

total number of animals: 86

Control animals:

not specified

Details on study design:

observation of the animals for 7 days after the administration of hafnyl chloride

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

112 mg/kg bw

Based on:

not specified

95% CL:

93.3 - 134.4

Mortality:

The first deaths occurred within 24 hours but the peak was not reached until 48 hours. A few animals survived until the sixth day of the study.

Clinical signs:

other: The symptoms of acute toxicity were immediate urination and lethargy.

Applicant's summary and conclusion

Executive summary:

The intraperitoneal LD₅₀was determined on 86 male CF-1 mice and was found to be 112 mg/kg (93.3-134.4) for hafnyl chloride (HfOCl₂), for 7 days. The symptoms of acute toxicity were immediate urination and lethargy. The first deaths occurred within 24 hours but the peak was not reached until 48 hours. A few animals survived until the sixth day of the study.