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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study not performed according to GLP, no details provided regarding experimental design (doses, number of animals) and observation only for 7 days, but data are well documented and scientifically acceptable.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
The toxicologic and pharmacologic effects of hafnium salts
Author:
Haley TJ, Raymond K, Komesu N, Upham HC
Year:
1962
Bibliographic source:
Toxicology and applied pharmacology 4, 238-246

Materials and methods

Principles of method if other than guideline:
No details available on method. The acute toxicity was investigated by intraperitoneal route for 7 days.
GLP compliance:
no
Test type:
other: intraperitoneal LD50

Test material

Constituent 1
Reference substance name:
Hafnyl chloride (HfOCl2)
IUPAC Name:
Hafnyl chloride (HfOCl2)
Details on test material:
hafnium chloride 98.5% purity, no other details

Test animals

Species:
mouse
Strain:
CF-1
Sex:
male

Administration / exposure

Route of administration:
other: intraperitoneal
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
no data
No. of animals per sex per dose:
total number of animals: 86
Control animals:
not specified
Details on study design:
observation of the animals for 7 days after the administration of hafnyl chloride

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
112 mg/kg bw
Based on:
not specified
95% CL:
93.3 - 134.4
Mortality:
The first deaths occurred within 24 hours but the peak was not reached until 48 hours. A few animals survived until the sixth day of the study.
Clinical signs:
other: The symptoms of acute toxicity were immediate urination and lethargy.

Applicant's summary and conclusion

Executive summary:

The intraperitoneal LD50was determined on 86 male CF-1 mice and was found to be 112 mg/kg (93.3-134.4) for hafnyl chloride (HfOCl2), for 7 days. The symptoms of acute toxicity were immediate urination and lethargy. The first deaths occurred within 24 hours but the peak was not reached until 48 hours. A few animals survived until the sixth day of the study.