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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study not performed according to GLP but data are well documented and scientifically acceptable
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
The toxicologic and pharmacologic effects of hafnium salts
Author:
Haley T.J., Raymond K., Komesu N. and Upham H.C.
Year:
1962
Bibliographic source:
Toxicology and applied pharmacology, vol 4: 238-246

Materials and methods

Principles of method if other than guideline:
Three rabbits received 1 mg of hafnium chloride placed in one eye.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
hafnyl chloride (HfOCl2)
IUPAC Name:
hafnyl chloride (HfOCl2)
Test material form:
not specified

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Observation period (in vivo):
24 hours
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Irritant / corrosive response data:
This exposition resulted in an immediate increase in the rate of blinking and a redness of the palpebral conjunctiva within 1 hour.
At 24 hours, there was no evidence of corneal or iris damages, conjuctival irritation, chemosis or increased lacrimal discharge.

According to the author, the natural buffering capacity of the lacrimal fluid was sufficient to counteract the nascent hydrochloric acid released when the hafnium chloride dissolved in the lacrimal fluids.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Executive summary:

Three rabbits had 1 mg of hafnium chloride placed in one eye to complete the study of ocular irritation. This exposition resulted in an immediate increase in the rate of blinking and a redness of the palpebral conjunctiva within 1 hour. At 24 hours, there was no evidence of corneal or iris damages, conjuctival irritation, chemosis or increased lacrimal discharge. According to the author, the natural buffering capacity of the lacrimal fluid was sufficient to counteract the nascent hydrochloric acid released when the hafnium chloride dissolved in the lacrimal fluids.