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EC number: 203-378-7 | CAS number: 106-25-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2 -9 July 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- GLP study conducted according to OECD Guideline 404 with minor deviation: individual animal weights not reported.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- individual animal weights not reported
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- Nerol
- EC Number:
- 203-378-7
- EC Name:
- Nerol
- Cas Number:
- 106-25-2
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-2,6-dien-1-ol
- Test material form:
- liquid
- Details on test material:
- Name of test material (as cited in study report): NEROL 900A 575700 998
Physical state: colourless liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: David Percival Ltd., Sandbach, UK.
- Age at study initiation: Approximately 12-16 weeks
- Weight at study initiation: 2.50-2.72 kg
- Housing: Animals were housed individually in suspended metal cages.
- Diet: Food (Rabbit diet, Preston Farmers Limited, New Leake, UK), ad libitum
- Water: Mains drinking water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 18-21 °C
- Humidity: 60-65 %
- Air changes: Approximately 15 changes/h
- Photoperiod: 12 h dark / 12 h light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (weight with unit): 0.5 mL
- Concentration (if solution): Undiluted test item - Duration of treatment / exposure:
- 4 h
- Observation period:
- 1, 24, 48 and 72 h and 7 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal/flank area
- Type of wrap if used: Test item was introduced under a 2.5 cm x 2.5 cm gauze patch and placed in position on the shorn skin. The patch was secured in position with a strip of surgical adhesive tape (BLENDERM: approximate size 25 mm x 40 mm). To prevent the animals interfering with the patches, the trunk of each rabbit was wrapped in an elasticated corset (TUBIGRIP) and the animals were returned to their cages for the duration of the exposure period.
REMOVAL OF TEST SUBSTANCE
- Four hours after application the corset and patches were removed from each animal and any residual test material removed by gentle swabbing with cotton wool soaked in distilled water.
- Time after start of exposure: 4 h
SCORING SYSTEM: According to OECD Guideline 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- mean individual score
- Time point:
- other: 24, 48 and 72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- mean individual score
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- mean individual score
- Time point:
- other: 24, 48 and 72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- mean individual score
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- mean individual score
- Time point:
- other: 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- mean individual score
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritant / corrosive response data:
- - Very slight erythema was noted at one treated skin site one hour after removal of the patches.
- The irritation increased and very slight to well-defined erythema with or without very slight oedema was noted at all treated skin sites at subsequent 24, 48 and 72 h observations.
- Hyperkeratinisation of the skin was noted at all treated skin sites on Day 7.
- No corrosive effects were noted. - Other effects:
- None
Any other information on results incl. tables
Table 7.3.1/1: Results of skin irritation
Skin reaction |
Reading (h) |
Individual scores – Rabbit no. |
||
90 |
119 |
124 |
||
Erythema/Eschar formation |
1 |
0 |
0 |
1 |
24 |
1 |
1 |
2 |
|
48 |
2 |
2 |
2 |
|
72 |
2 |
2 |
2 |
|
7 days |
H |
H |
H |
|
Mean (24, 48 and 72 h) |
1.7 |
1.7 |
2.0 |
|
Oedema formation |
1 |
0 |
0 |
0 |
24 |
0 |
0 |
1 |
|
48 |
1 |
0 |
1 |
|
72 |
1 |
0 |
0 |
|
7 days |
0 |
0 |
0 |
|
Mean (24, 48 and 72 h) |
0.7 |
0.0 |
0.7 |
H: Hyperkeratinisation over whole of test site
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Nerol induced an hyperkeratinisation of the skin on Day 7. Based on the absence of information on the reversibility of this effect, this substance is classified as irritating to skin according to Directive 67/548/EEC and nerol is classified in Category 2 (irritant) according to CLP Regulation (EC) N° 1272/2008.
- Executive summary:
In a primary dermal irritation study performed according to OECD Guideline 404 and in compliance with GLP, three New Zealand white rabbits were dermally exposed to 0.5 mL of nerol under a semi-occlusive dressing for 4 h. After removal of the residual test item, irritation was scored as outlined in OECD Guideline 404 at 1, 24, 48 and 72 h and 7 days after exposure.
Very slight erythema was noted at one treated skin site one hour after removal of the patches. The irritation increased and very slight to well-defined erythema with or without very slight oedema was noted in all treated skin sites at subsequent 24, 48 and 72 h observations. Hyperkeratinisation of the skin was noted in all treated skin sites on Day 7. No corrosive effects were noted. Mean individual scores at 24, 48 and 72 h after exposure for the 3 animals were 1.7, 1.7, 2.0 for erythema and 0.7, 0.0, 0.7 for oedema score, respectively.
Thus, nerol induced an hyperkeratinisation of the skin on Day 7. Based on the absence of information on the reversibility of this effect, this substance is classified as irritating to skin according to Directive 67/548/EEC and nerol is classified in Category 2 (irritant) according to CLP Regulation (EC) N° 1272 /2008.
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