Registration Dossier
Registration Dossier
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EC number: 211-560-2 | CAS number: 665-66-7
Density
Administrative data
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- pycnometer method
Test material
- Reference substance name:
- Amantadine hydrochloride
- EC Number:
- 211-560-2
- EC Name:
- Amantadine hydrochloride
- Cas Number:
- 665-66-7
- Molecular formula:
- C10H17N.ClH
- IUPAC Name:
- adamantan-1-amine hydrochloride
- Test material form:
- other: solid
- Details on test material:
- Name of test material (as cited in study report): 1-Aminoadamantanhydrochlrid
Analytical purity: 99.7 g/100g by 1H-NMR spectroscopy using the internal standard method (determined during the GLP-study No.
11 L00389 from Competence Center Analytics, BASF SE)
Lot/batch No.: 20110315
Constituent 1
Results and discussion
Density
- Type:
- relative density
- Density:
- 1.172
- Temp.:
- 20 °C
Any other information on results incl. tables
Density determination of the test item:
| 1st determination | 2nd determination | ||
| A | Mass of pycnometer empty (corrected for air) |
37.43033 | 36.9902 cm3 |
| B | Mass of pycnometer with test item (corrected for air) |
50.3611 | 51.0658 |
| C | Mass of pycnometer with test item and displacement liquid |
61.4230 | 61.3213 |
| D | Mass of displacement liquid calculated for the total pycnometer volume |
19.8085 | 19.7791 |
| E | Mass of test item (B - A) | 12.9308 | 14.0756 |
| F | Mass of displacement liquid (C - B) | 11.0619 | 14.0756 |
| G | Mass of displacement liquid calculated for the volume taken by the test item (D - F) |
8.7466 | 9.5236 |
| H | Density of the test item (E/G * density of displacement liquid) |
1.1725 g/cm3 | 1.1722 g/cm3 |
| I | Relative density D204(H/density of water at 4°C) |
mean: 1.172 | |
volume of 1st pycnometer: 24.976 cm3; volume of 2nd pycnometer: 24.939 cm3
Masses are listed in gram. Results are calculated with not rounded single values.
Measuring temperature = 20 °C
The relative density was calculated by division of the density of test item at 20°C and the density of water at 4 °C.
The test item is solid at room temperature.
D4/20 = 1.172
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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