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Physical & Chemical properties

Density

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Administrative data

Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
GLP compliance:
yes (incl. QA statement)
Type of method:
pycnometer method

Test material

Constituent 1
Chemical structure
Reference substance name:
Amantadine hydrochloride
EC Number:
211-560-2
EC Name:
Amantadine hydrochloride
Cas Number:
665-66-7
Molecular formula:
C10H17N.ClH
IUPAC Name:
adamantan-1-amine hydrochloride
Test material form:
other: solid
Details on test material:
Name of test material (as cited in study report): 1-Aminoadamantanhydrochlrid
Analytical purity: 99.7 g/100g by 1H-NMR spectroscopy using the internal standard method (determined during the GLP-study No.
11 L00389 from Competence Center Analytics, BASF SE)
Lot/batch No.: 20110315

Results and discussion

Density
Type:
relative density
Density:
1.172
Temp.:
20 °C

Any other information on results incl. tables

Density determination of the test item:

    1st determination 2nd determination
A Mass of pycnometer empty
(corrected for air)
37.43033 36.9902 cm3
B Mass of pycnometer with test item
(corrected for air)
50.3611 51.0658
C Mass of pycnometer with test item and
displacement liquid
61.4230 61.3213
D Mass of displacement liquid calculated for
the total pycnometer volume
19.8085 19.7791
E Mass of test item (B - A) 12.9308 14.0756
F Mass of displacement liquid (C - B) 11.0619 14.0756
G Mass of displacement liquid calculated for
the volume taken by the test item (D - F)
8.7466 9.5236
H Density of the test item
(E/G * density of displacement liquid)
1.1725 g/cm3  1.1722 g/cm3
I Relative density D204(H/density of water
at 4°C)
mean: 1.172

volume of 1st pycnometer: 24.976 cm3; volume of 2nd pycnometer: 24.939 cm3

Masses are listed in gram. Results are calculated with not rounded single values.

Measuring temperature = 20 °C

The relative density was calculated by division of the density of test item at 20°C and the density of water at 4 °C.

The test item is solid at room temperature.

D4/20 = 1.172

Applicant's summary and conclusion