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Description of key information

Hydrolysis

On the basis of the experimental study results of the test chemical and applying the weight of evidence approach, test chemical was considered to be stable in water.

Additional information

Hydrolysis

Data available for its read across chemicals has been reviewed to determine the hydrolysis half-life of the test chemical in water. The studies are as mentioned below:

 

The half-life of the test chemical was determined. Test chemical concentrations were analyzed using HPLC. Duplicate samples from the mid-layer of each batch were analyzed every 24 hours for stability. The 0 hours samples were also used to determine intra-day variation. The results were considered to be acceptable when the precision was within 10% and the variation of stability was +/-20% of the original concentration. The analyses of maintenance water and OECD medium were conducted until 96 and 72 hours, respectively. The precision and variation of reananlyzed 100 microgarm/ml of test solutions for confirmation stability were within 0.60% and -9.49% of the original concentrations following storage in maintenance water for 96 hours. On the other hand, the precision and variation of reananlyzed 1100 microgarm/ml test solutions for confirmation stability were within 6.99-1.05% and -1.05 to -1.68% of the original concentrations following storage in OECD medium for 72 hours. Thus, the half-life value of test chemical in water was evaluated to be >96 hrs, indicating that the test chemical was considered to be hydrolytically stable in water.

 

In an another study, the half-life of the test chemical was determined. Test chemical does not undergo hydrolysis in a 28 day study. Thus, half-life of test chemical was evaluated to be >28 days, indicating that the test chemical is stable in water.

 

On the basis of the experimental study results of the test chemical and applying the weight of evidence approach, test chemical was considered to be hydrolytically stable.