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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from ECOSAR version 1.11
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
Long term toxicity was predicted from ECOSAR version 1.1.
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material : Sodium Cocoyl glutamate
- Substance type: organic
- Physical state: solid
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Details on test organisms:
- Common name: Water flea
Test type:
not specified
Water media type:
not specified
Total exposure duration:
21 d
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
13.477 mg/L
Nominal / measured:
estimated
Conc. based on:
not specified
Basis for effect:
not specified
Remarks on result:
other: Nontoxic
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of no effects observed on a freshwater aquatic invertebrates, the NOEC value for the substance is estimated to be 13.477 mg/l for daphnia for 21 days of exposure duration.
Executive summary:

Based on the prediction done using ECOSAR version 1.1, the long term toxicity on aquatic invertebrates was predicted for test substance  l-Glutamic acid, N-coco acyl derivs., monosodium salts (68187 -32 -6). On the basis of no effects observed on a freshwater aquatic invertebrates, the NOEC value for the substance is estimated to be 13.477 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical l-Glutamic acid, N-coco acyl derivs., monosodium salts can be considered as non-toxic to daphnia at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria. 

Description of key information

Based on the prediction done using ECOSAR version 1.1, the long term toxicity on aquatic invertebrates was predicted for test substance  l-Glutamic acid, N-coco acyl derivs., monosodium salts (68187 -32 -6). On the basis of no effects observed on a freshwater aquatic invertebrates, the NOEC value for the substance is estimated to be 13.477 mg/l for daphnia for 21 days of exposure duration. Based on this value, it can be concluded that the test chemical l-Glutamic acid, N-coco acyl derivs., monosodium salts can be considered as non-toxic to daphnia at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria. 

Key value for chemical safety assessment

Additional information

This end point was considered for waiver in accordance with column 1 of Annex IX wherein data has been provided for short term toxicity to aquatic invertebrate. In addition, this chemical is readily bio-degradable in water and coupled with the dilution potential in the aquatic environment, the chemical is not expected to cause long term toxicity to aquatic invertebrate