Registration Dossier

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from ECOSAR
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
Long term toxicity of test chemical were determine on the freshwater aquatic invertebrate daphnia magna.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
- Water flea
Test type:
flow-through
Water media type:
not specified
Total exposure duration:
21 d
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
1.534 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
immobilisation
Remarks on result:
other: Other details not known
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of effects observed in a freshwater system, the NOEC value for the substance is estimated to be 1.534 mg/l for aquatic invertebrate for 21 days of exposure duration.
Executive summary:

Based on the prediction done using ECOSAR version, the long term toxicity on aquatic invertebrate was predicted for test substance. On the basis of effects observed in a flow-through freshwater system, the NOEC value for the substance is estimated to be 1.534 mg/l for aquatic invertebrate for 21 days of exposure duration. Since, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

Description of key information

Based on the prediction done using ECOSAR, the long term toxicity on aquatic invertebrate was predicted for test substance. On the basis of effects observed in a flow-through freshwater system, the NOEC value for the substance is estimated to be 1.534 mg/l for aquatic invertebrate for 21 days of exposure duration. Since, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1.534 mg/L

Additional information

Data available for test chemicals including structurally and functionally similar read across chemical, study has been reviewed to determine the long term toxicity of the test chemical on the growth and reproduction of daphnia magna. The studies are as mentioned below:

 

Based on the prediction done using ECOSAR version, the long term toxicity on aquatic invertebrate was predicted for test substance. On the basis of effects observed in a flow-through freshwater system, the NOEC value for the substance is estimated to be 1.534 mg/l for aquatic invertebrate for 21 days of exposure duration. Since, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

 

Long term toxicity of test chemical were studied on the reproduction of test organism daphnia magna. Test conducted in accordance with OECD Test Guideline 202. 5 nominal concentrations (0.78-78 mg/l) were used for the study and performed under the closed static system. 9:1 DMSO:HCO-40 used as a vehicle. 4 replicates; 10 organisms per replicate) were exposed at the nominal concentrations. Effects were observed in the interval of 24 hrs, 48 hrs, 72 hrs, 96 hrs, 7 days and 14 days. Based on the effects observed on the mortality and reproduction of freshwater daphnia magna by the test chemical effects were observed. On the basis of mortality, the LC50 after 21 days were determine to be 2.6 mg/l and on the basis of effects on reproduction, the EC50 was 1.6 mg/l. The NOEC was observed at 0.78 mg/l and LOEC at 2.5 mg/l. Based on the LC50 and EC50, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

 

Thus based on the EC50 and LC50, chemical consider to be nontoxic and not classified as per the CLP classification criteria.