Registration Dossier
Registration Dossier
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EC number: 205-533-4 | CAS number: 142-30-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP near guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- According to BASF-internal standard
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,5-dimethylhexyne-2,5-diol
- EC Number:
- 205-533-4
- EC Name:
- 2,5-dimethylhexyne-2,5-diol
- Cas Number:
- 142-30-3
- Molecular formula:
- C8H14O2
- IUPAC Name:
- 2,5-dimethylhex-3-yne-2,5-diol
- Details on test material:
- - Name of test material (as cited in study report): Dimethylhexindiol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 9 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: Lying on the stomach and in the lateral position, dyspnea, twitching, anesthesia-like condition, slight apathy, trembling, reddish encrusted eyes and nose were observed.
- Gross pathology:
- Acute cardiac dilatation with stasis, bloody stomach ulcers (in the glandular stomach) and diarreal content were observed.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
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