Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 242-894-7 | CAS number: 19224-26-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key data is available for propylene glycol dibenzoate (PGDB). This data is supported by relevant information available from a structural analogue Dipropylene glycol dibenzoate (DPGDB). The justification for read across is presented as an attachment included in Section 13 of the IUCLID dossier.
Hydrolysis
In studies performed to OECD guidelines and GLP, propylene glycol dibenzoate was determined to be readily biodegradable, hydrolytically unstable under basic conditions and possibly adsorbing to soil.
Propylene glycol dibenzoate was hydrolytically stable under acidic and neutral conditions, but unstable under basic conditions with a half-life of 9 days in an OECD Guideline 111 (hydrolysis as a function of pH) test performed to GLP guidelines (Huntingdon Life Sciences, 2014b; Klimisch Score = 1).
Biodegradation
Mean oxygen consumption in mixtures containing PGDB was 7% of the theoretical value (25 mgO2/500 mL) after 1 day, 32% after 2 days, 60% after 7 days and 81% at the end of the test (Day 28). Therefore, PGDB was considered to be readily biodegradable under the conditions of the OECD Guideline 301 F, Ready Biodegradability: Manometric Respirometry Test (Huntingdon Life Sciences, 2014c; Klimisch score = 1).
In a modified Sturm test (Huntingdon Life Sciences, 1998a; Klimisch score = 1), DPGDB was found to have degraded by 6% after 2 days, 62% after 12 days, and by 85% at the end of the 28 -day biotic phase of the test.
Substances are considered to be readily degradable in this test if CO2 production is equal to or greater than 60% of the theoretical value within ten days of the level achieving 10%. In the Modified Sturm test, DPGDB met these criteria, so may be considered to be readily biodegradable. The BOD / COD studies show DPGDB to be inherently biodegradable and the anaerobic study showed it to be anaerobically biodegradable.
In accordance with the adaptations found in column 2 of Annex IX, simulation studies of biodegradation in water, sediments and soils are waived due to the demonstrated ready biodegradation of the substance.
Bioaccumulation
According to the adaptations found in column 2 of annex IX, the bioconcentration in aquatic species study can be waived if direct and indirect exposure to the aquatic environment is unlikely. This substance has no defined uses where direct application to the aquatic environment would occur, and because the substance is readily biodegradable, wastewater treatment would also make indirect exposure to the aquatic environment unlikely. In addition, evidence of a low bioaccumulation potential is provided by QSAR estimates showing BCF values < 100 L/kg using a regression method based upon the experimental log Kow value of 3.2, and using the Arnot-Gobas QSAR method the BCF/BAF values for all trophic levels are < 10 L/kg when biotransformation rates are utilized and ~ 200 L/kg when biotransformation is not included in the estimation. For these reasons, and for animal welfare reasons, it is believed that a bioconcentration study is not justified and is not proposed.
Transport and distribution
PGDB may exhibit some immobility in the soil as suggested by the soil partition coefficient ofpropylene glycol dibenzoatemeasured as 4400 (log10Koc value of 3.6) in a study performed to OECD 121 guideline (Huntingdon Life Sciences, 2014a; Klimisch Score = 1). However it was deemed readily biodegradable in the "manometric respirometry test" (OECD 301F). QSAR prediction shows that the substance has a low potential to bioaccumulate.
Dipropylene glycol dibenzoate was determined to have a log10Koc valueof 3.6 (equivalent Koc = 3.981 x 103) at 20°C (Huntingdon Life Sciences, 1999b; Klimisch Score = 1).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.