Registration Dossier
Registration Dossier
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EC number: 242-894-7 | CAS number: 19224-26-1
Endpoint summary
Administrative data
Description of key information
PGDB
The BCF of propylene glycol dibenzoate is 173.9 L/Kg wet-wt showing that the substance has a low potential to bioaccumulate.
Hydrolysis products are propylene glycol and benzyl alcohol molecules that are significantly more polar than the parent PGDB and therefore can be
considered not to be bioaccumulative. The major metabolite, the monobenzoate analogue is, similarly, more polar than the parent molecule, and therefore bioaccumulation potential for this must also be low.
DPGDB
According to the adaptations found in column 2 of annex IX, the bioconcentration in aquatic species study can be waived if direct and indirect exposure to the aquatic environment is unlikely. This substance has no defined uses where direct application to the aquatic environment would occur, and because the substance is readily biodegradable, wastewater treatment would also make indirect exposure to the aquatic environment unlikely. In addition, evidence of a low bioaccumulation potential is provided by QSAR estimates showing BCF values < 200 L/kg using a regression method based upon the experimental log Kow value of 3.9 (HLS 1998, VCL249/972399) and using the Arnot-Gobas QSAR method the BCF/BAF values for all trophic levels are < 10 L/kg when biotransformation rates are utilized. For these reasons, and for animal welfare reasons, it is believed that a bioconcentration study is not justified and is not proposed.
Additional information
Bioaccumulation: terrestrial
No data available. No data required.
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