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EC number: 236-948-9 | CAS number: 13560-89-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- single administration
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Klimisch Rating 2, purity and physicochemical properties of the test substance not given, age of test organism not given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- signs of systemic toxicity besides mortality not recorded
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,6,7,8,9,14,15,16,17,17,18,18-dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene
- EC Number:
- 236-948-9
- EC Name:
- 1,6,7,8,9,14,15,16,17,17,18,18-dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene
- Cas Number:
- 13560-89-9
- Molecular formula:
- C18H12Cl12
- IUPAC Name:
- 1,2,3,4,7,8,9,10,13,13,14,14-dodecachloro-1,4,4a,5,6,6a,7,10,10a,11,12,12a-dodecahydro-1,4:7,10-dimethanodibenzo[a,e][8]annulene
- Test material form:
- solid - liquid: suspension
- Details on test material:
- Dechlorane Plus, tested as a 50% W/V suspension in water containing 0.5% tween 80
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No details reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water containing 0.5% tween 80
- Details on oral exposure:
- animals starved for 24 hours followed by single gavage administration
- Doses:
- 1,500, 3,000, 6,000, 12,500, 25,000 mg/kg bodyweight
- No. of animals per sex per dose:
- 3 males and 2 females per dose
- Control animals:
- no
- Details on study design:
- Administration followed by a 14 days postdose observation period, only mortality recorded, no recording of signs of systemic toxicity besides mortality
- Statistics:
- none
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 25 000 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: no toxic effect observed
- Mortality:
- none
- Clinical signs:
- other: none reported
- Gross pathology:
- not determined
- Other findings:
- none reported
Any other information on results incl. tables
Dose level Dose level Day - Mortality
ml/kg mg/kg 1 2 3 4 5 6 7 8 9 10 11 12 13 14 total
3.0 1,500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
6.0 3,000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
12.0 6,000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
25.0 12,500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
50.0 25,000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Not toxic according to EU criteria, LD50 > 25000 kg/kg bw
- Executive summary:
Groups of 3 male and 2 female rats were given Dechlorane Plus as suspension in aqueous methylcellulose once orally at dose levels of 1,500, 3,000, 6,000, 12,500, or 25,000 mg/kg bw by gavage and were observed for 14 days for mortality. No mortality occurred. The NOEL was determined at 25,000 mg/kg bw. Dechlorane Plus was nontoxic.
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