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EC number: 244-005-8 | CAS number: 20748-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable non-GLP study, comparable to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not applicable
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Before OECD Guideline 405 was first adopted in 1981, eye irritation was tested using a BASF test.
The methods were based on Draize (Federal Register 38, No. 187, § 1500.42, p. 27019 (1973-09-27)). - GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxyethylammonium chloride
- EC Number:
- 217-900-6
- EC Name:
- 2-hydroxyethylammonium chloride
- Cas Number:
- 2002-24-6
- IUPAC Name:
- 2-hydroxyethanaminium chloride
- Details on test material:
- - Name of test material: Härter 421 flüssig; Äthanolaminhydrochlorid 45 % (German)
- Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 100 µL - Duration of treatment / exposure:
- single treatment
- Observation period (in vivo):
- not reported (the standard duration of the observation period in the BASF test on eye irritation was 7 or 8 days)
- Number of animals or in vitro replicates:
- 6 rabbits (4 males, 2 females)
- Details on study design:
- SCORING SYSTEM:
Draize scoring system
Based on the Draize scores, a primary irritation index was calculated (max. score: 110).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- (animals #1, #3, #4, #6)
- Time point:
- other: 24/48/72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- (animal #2)
- Time point:
- other: 24/48/72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: finding noted at 72 hours only (score 1)
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- (animal #5)
- Time point:
- other: 24/48/72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: finding noted at 72 hours only (score 1)
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- (all animals)
- Time point:
- other: 24/48/72 hours
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- (animal #1)
- Time point:
- other: 24/48/72 hours
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- (animal #2)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- (animal #3)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- (animal #4)
- Time point:
- other: 24/48/72 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- (animal #5)
- Time point:
- other: 24/48/72 hours
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- (animal #6)
- Time point:
- other: 24/48/72 hours
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- (animals #1, #2, #3, #4, #5)
- Time point:
- other: 24/48/72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- (animal #6)
- Time point:
- other: 24/48/72 hours
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: finding noted at 24 hours only (score 2)
- Irritant / corrosive response data:
- Slight conjunctival redness was the main test substance-related finding noted in 5/6 rabbits with mean scores (24/48/72 hours) ranging from 0.67 to 1.33. In 1/6 animals chemosis was observed after 24 hours resulting in a mean chemosis score of 0.67 for this rabbit. In 2/6 rabbits a very slight corneal opacity was noted at the 72-hours reading resulting in a mean score (24/48/72 hours) of 0.33 for each of the two rabbits. Reversibility was not assessed in this study (no 8-day observation reported); however there was a general trend towards reversibility within the 72-hour observation period.
The primary irritation index was calculated to be 3.0.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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