Registration Dossier
Registration Dossier
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EC number: 205-355-7 | CAS number: 139-13-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: restriction: short study description; original data not available
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 968
Materials and methods
- Principles of method if other than guideline:
- no information about test method
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- Trisodium nitrilotriacetate
- EC Number:
- 225-768-6
- EC Name:
- Trisodium nitrilotriacetate
- Cas Number:
- 5064-31-3
- IUPAC Name:
- trisodium 2,2',2''-nitrilotriacetate
- Details on test material:
- NTA monohydrate, 25% aqueous solution
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Duration of exposure:
- up to 24 hours
- Doses:
- 1000, 1580, 2510, 3980, 6310, 10000 mg/kg
- No. of animals per sex per dose:
- 1
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Clinical signs:
- other: No nervousness or muscular incoordination developed. Activity and appetite reduced for 2-3 days at the higher levels; mild weakness.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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