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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Two in vitro studies of genotoxicty - one on bacteria and one on mammalian cells - are submitted. Both give a negative result. An additional in vivo study on genotoxicty - a micronucleas assay - is submitted. This also gives a negative result.

It is concluded that N-(n-octyl)-2-pyrrolidinone is not genotoxic.

Justification for selection of genetic toxicity endpoint
The study has been completed to modern guidelines, and to GLP standards.

Short description of key information:
N-(n-octyl)-2-pyrrolidinone is found not to have any genotoxic potential.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

No classification is required since both studies show N-(n-octyl)-2-pyrrolidinone does not have genotoxic potential.