Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The skin sensitization potential of the whole range of alcohol ethoxylates (AEs) was evaluated by the majority in the guinea pig maximisation test according to the Magnusson Kligman and in the non-adjuvant Buehler test protocol in guinea pigs.

In summary, all of the six studies conducted with the Cas-No. 71060-57-6, 68439-50-9, 68551-12-2, 66455-14-9, 68131-39-5 and 68439-49-6 showed that the AEs have no skin sensitizing potential. Hence, no classification is warranted. This is further supported by clinical data that demonstrate the absence of skin sensitization responses to AE when tested under the conditions of the HRIPT (HERA, 2009).

Migrated from Short description of key information:
Buehler and GPMT (OECD 406): not sensitising

Justification for selection of skin sensitisation endpoint:
No study chosen due to woe approach.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:
Migrated from Short description of key information:
No data available.

Justification for classification or non-classification

Classifcation criteria for skin sensitisation according to 67/548/EEC and (EC)1272/2008 are not fulfilled. No data available for respiratory sensitisation.