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EC number: 300-227-8 | CAS number: 93924-33-5 A distillate obtained from the redistillation of a complex combination of hydrocarbons obtained by the distillation of the effluents from a severe catalytic hydrotreatment of paraffins. It boils in the range of approximately 190°C to 330°C (374°F to 594°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981-10-28 to 1982-08-04
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable and a well-documented study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Eyes were flushed 30 seconds after treatment. OECD TG 405 suggests flushing to occur after 24 hours of treatment.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Hydrodesulfurised middle distillate (CAS# 64742-80-9)
- IUPAC Name:
- Hydrodesulfurised middle distillate (CAS# 64742-80-9)
- Details on test material:
- - Name of test material (as cited in study report): API 81-09 (CAS# 64742-80-9)
- Physical state: Clear liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Dutchland Laboratories, Inc., Denver, Pennsylvania
- Age at study initiation: Young adults
- Weight at study initiation: Approximately 2.5 to 3.5 kg
- Housing: individual screen bottom cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-22 degrees Celsius
- Humidity (%): 40% to 58% relative humidity
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12 hours dark/ 12 hours light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The contralateral eye was used as the untreated control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL of the liquid test material was placed in the eye.
VEHICLE - no vehicle was used. - Duration of treatment / exposure:
- Group II animals had the treated eye flushed for one minute with lukewarm water starting 30 seconds after compound instillation. The eyes of rabbits in Group I remained unflushed.
- Observation period (in vivo):
- Ocular lesions in the treated eyes were observed 1, 48, 72 hours and at 7 days after treatment. Sodium fluorescein and ultraviolet light were used to reveal possible corneal injury at 72 hours and 7 days after treatment.
- Number of animals or in vitro replicates:
- Nine male and female rabbits.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Rabbits in Group II had eye flushed with lukewarm water for one minute after exposure. Treated eyes in Group I remained unflushed.
- Time after start of exposure: 30 seconds
SCORING SYSTEM: Draize method
TOOL USED TO ASSESS SCORE: sodium fluorescein and ultraviolet light
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- unwashed
- Time point:
- other: 24 hours
- Score:
- 2
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: Individual animal data were not provided.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The mean overall eye irritation score for unwashed animals was reported as 2.0 at 24 hours. Irritation was reversible at 48 hours post exposure. Hydrodesulfurised middle distillate was not classified as irritating because individual animal irritation data was not provided.
- Executive summary:
In a primary eye irritation study, 0.1 mL of test material (Hydrodesulfurised middle distillate) was instilled into the conjunctival sac of the left eye of young adult New Zealand White rabbits (4 male/5 female). The right eye of the animals were used as the control. Rabbits in Group II had the treated eye washed for one minute after 30 seconds of treatment. Rabbits treated in Group I remained unwashed for the entire observation period. Animals were observed for seven days. Irritation was scored by the method of Draize.
The maximum primary irritation score for Group I (unwashed) was 2.7 at 1 hour and 2.0 at 24 hours. Irritation was reversed at 48 hours. The primary irritation score for Group II (washed) was 2.7 at 1 hour. Irritation was reversible at 24 hours. Hydrodesulfurised middle distillate is considered non-irritating to the rabbit eye because of the low irritation score and reversibility, and is not classified as irritating because individual animal irritation data was not provided.
This study received a Klimisch score of two and is classified as reliable with restriction because it is an acceptable and a well-documented study report.
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